Relationship between lactate dehydrogenase activity in saliva and oral health status
| Autor: | Pedro Diz Dios, Víctor Alonso de la Peña, Rafael Tojo Sierra |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Saliva Adolescent Oral Hygiene Index Dentistry Physiology Oral Health Oral health chemistry.chemical_compound stomatognathic system Periodontal disease Predictive Value of Tests Lactate dehydrogenase Humans Medicine General Dentistry Periodontal Diseases Aged Aged 80 and over L-Lactate Dehydrogenase business.industry Calculus (dental) Dental prosthesis Mouth Mucosa Cell Biology General Medicine Middle Aged medicine.disease Temporomandibular joint stomatognathic diseases medicine.anatomical_structure Otorhinolaryngology chemistry Multivariate Analysis Female Ldh activity business Biomarkers |
| Zdroj: | Archives of Oral Biology. 52:911-915 |
| ISSN: | 0003-9969 |
| DOI: | 10.1016/j.archoralbio.2007.04.008 |
| Popis: | Objective Lactate dehydrogenase (LDH) activity in serum increases as a marker of cellular necrosis. LDH activity in saliva could constitute a specific indicator of oral mucosal lesions with tissue breakdown including periodontal disease. The aim of this study was to determine LDH activity in saliva, assessing inter-individual variations with regard to the oral health status. Materials and methods An oral and perioral examination was performed on a study group of 175 volunteers, to assess the number of missing teeth, caries, fillings, dental prosthesis, periodontal status and temporomandibular joint condition. LDH activity was determined from stimulated whole saliva. Results After adjustment by age, gender, smoking habits, missing teeth and use of removable prosthesis, the multivariate analysis showed that increased LDH activity was associated with periodontal disease, specifically with the presence of calculus and pockets greater than 5 mm. Conclusion LDH activity in whole saliva could be useful as a biochemical marker of periodontal status. |
| Databáze: | OpenAIRE |
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