Histomorphometric Analysis Reveals Reduced Bone Mass and Bone Formation in Patients With Quiescent Crohn's Disease
| Autor: | Oostlander, A.E., Bravenboer, N., Sohl, E., Holzmann, P.J., Woude, C.J. van der, Dijkstra, G., Stokkers, P.C.F., Oldenburg, B., Netelenbos, J.C., Hommes, D.W., Bodegraven, A.A. van, Lips, P., Dutch Initiative Crohn Colitis ICC |
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| Přispěvatelé: | Research Institute MOVE, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), Groningen Institute for Organ Transplantation (GIOT), Internal medicine, Clinical chemistry, Epidemiology and Data Science, Gastroenterology and hepatology, MOVE Research Institute, CCA - Innovative therapy, Other departments, Internal Medicine, Gastroenterology & Hepatology |
| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty Bone density Bone Histomorphometry GASTROINTESTINAL-DISEASE Osteoporosis Inflammatory bowel disease Bone resorption Pathogenesis Biopsy medicine Hepatology medicine.diagnostic_test Bone Histomorphometry Osteocyte Apoptosis Inflammatory Bowel Disease Osteoporosis inflammatory-bowel-disease osteocyte density gastrointestinal-disease postmenopausal women osteoporosis raloxifene OSTEOCYTE DENSITY business.industry Osteocyte Apoptosis Inflammatory Bowel Disease Gastroenterology medicine.disease Crohn's Disease Activity Index medicine.anatomical_structure POSTMENOPAUSAL WOMEN RALOXIFENE Osteocyte business INFLAMMATORY-BOWEL-DISEASE |
| Zdroj: | Gastroenterology, 140(1), 116-123. W.B. Saunders Ltd Gastroenterology, 140(1), 116-123. W B SAUNDERS CO-ELSEVIER INC Oostlander, A E, Bravenboer, N, Sohl, E, Holzmann, P J, van der Woude, C J, Dijkstra, G, Stokkers, P C F, Oldenburg, B, Netelenbos, J C, Hommes, D W, van Bodegraven, A A & Lips, P T A M 2011, ' Histomorphometric Analysis Reveals Reduced Bone Mass and Bone Formation in Patients With Quiescent Crohn's Disease ', Gastroenterology, vol. 140, no. 1, pp. 116-123 . https://doi.org/10.1053/j.gastro.2010.09.007 Gastroenterology, 140(1), 116-123. W.B. Saunders Gastroenterology, 140(1), 116-123 |
| ISSN: | 0016-5085 |
| Popis: | Background & Aims: Crohn's disease (CD) is associated with an increased prevalence of osteoporosis, but the pathogenesis of this bone loss is only partly understood. We assessed bone structure and remodeling at the tissue level in patients with quiescent CD. We also investigated the roles of osteocyte density and apoptosis in CD-associated bone loss. Methods: The study included 23 patients with quiescent CD; this was a subgroup of patients from a large randomized, double-blind, placebo-controlled, multicenter trial. We obtained transiliac bone biopsy samples and performed histomorphometric analysis. Results: were compared with data from age- and sex-matched healthy individuals (controls). Results: Trabecular bone volume was decreased among patients with CD compared with controls (18.90% vs 25.49%; P < .001). The low bone volume was characterized by decreased trabecular thickness (120.61 vs 151.42 μm; P < .01). Bone formation and resorption were reduced, as indicated by a decreased mineral apposition rate (0.671 vs 0.746 μm/day; P < .01) and a low osteoclast number and surface area compared with controls and published values, respectively. In trabecular bone of patients with CD, osteocyte density and apoptosis were normal. The percentage of empty lacunae among patients was higher than that of published values in controls. Conclusions:: In adult patients with quiescent CD, bone histomorphometric analysis revealed a reduction in bone mass that was characterized by trabecular thinning. The CD-associated bone loss was caused by reduced bone formation, possibly as a consequence of decreased osteocyte viability in the patients' past. © 2011 AGA Institute. |
| Databáze: | OpenAIRE |
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