Impact of preoperative breast MRI on 10-year survival outcome of patients included in the Swedish randomized multicenter POMB trial
| Autor: | Leif Bergkvist, L Löfgren, Kerstin Sandelin, Staffan Eriksson, Virginia Gonzalez, Brita Arver |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
re-excision AcademicSubjects/MED00910 Subgroup analysis Breast Neoplasms Preoperative care survival Disease-Free Survival Breast cancer breast cancer Statistical significance medicine Breast MRI Humans Sweden Cancer och onkologi medicine.diagnostic_test Proportional hazards model business.industry Hazard ratio Magnetic resonance imaging Bröstcancer General Medicine medicine.disease Magnetic Resonance Imaging Cancer and Oncology Randomized Clinical Trial Female Radiology Neoplasm Recurrence Local business AcademicSubjects/MED00010 MRI |
| Zdroj: | BJS Open |
| Popis: | Background The value of preoperative breast MRI as an adjunct technique regarding its effect on re-excision rates has been a subject of discussion. No survival data regarding preoperative breast MRI are available from randomized studies. Methods Ten-year follow-up of the POMB randomized multicentre study was analysed, evaluating MRI and its effect on disease-free survival (DFS) and overall survival (OS). Patients with newly diagnosed breast cancer were randomized to either preoperative MRI or conventional imaging. Kaplan–Meier plots were used to analyse DFS and OS, and Cox regression to estimate hazard ratios (HRs). Results A total of 440 patients, aged 56 years or less, with newly diagnosed breast cancer were randomized to either preoperative MRI (220) or conventional imaging (220; control). Median follow-up for each group was 10 years. DFS rates were 85.5 and 80.0 per cent for the MRI and control groups respectively (P = 0.099). The risk of relapse or death was 46 per cent higher in the control group (HR 1.46, 95 per cent c.i. 0.93 to 2.29). OS rates after 10 years were 90.9 and 88.6 per cent in the MRI and control groups respectively (P = 0.427). The risk of death was 27 per cent higher in the control group (HR 1.27, 0.71 to 2.29). Locoregional, distant, and contralateral recurrence outcomes combined were increased in the control group (P = 0.048). A subgroup analysis of patients with breast cancer stages I–III showed that preoperative MRI improved DFS compared with conventional imaging, but this did not reach statistical significance (P = 0.057). Conclusion After 10 years of follow-up, preoperative breast MRI as an adjunct to conventional imaging resulted in slightly, but non-significantly, improved DFS and OS. Registration number: NCT01859936 (http://www.clinicaltrials.gov). This 10-year follow-up of the POMB randomized multicentre study evaluated preoperative breast MRI in terms of disease-free survival (DFS) and overall survival (OS). DFS and OS were slightly but non-significantly improved. |
| Databáze: | OpenAIRE |
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