Use of serum inhibin B levels at the start of ovarian stimulation and at oocyte pickup in the prediction of assisted reproduction treatment outcome
| Autor: | Zoltán Papp, János Urbancsek, Thomas Strowitzki, Thomas Rabe, K. Klinga, Erik Hauzman |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Infertility endocrine system medicine.medical_specialty medicine.drug_class medicine.medical_treatment media_common.quotation_subject Fertilization in Vitro Andrology Ovulation Induction Predictive Value of Tests Pregnancy Internal medicine medicine Humans Endocrine system Inhibins reproductive and urinary physiology Retrospective Studies media_common In vitro fertilisation business.industry Pregnancy Outcome Obstetrics and Gynecology Prognosis medicine.disease Oocyte female genital diseases and pregnancy complications Endocrinology medicine.anatomical_structure Reproductive Medicine Case-Control Studies Oocytes Female Ovulation induction Reproduction Gonadotropin business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Fertility and Sterility. 83:341-348 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2004.06.065 |
| Popis: | Objective To assess whether serum inhibin B levels before gonadotropin administration and at oocyte pickup (OPU) are associated with pregnancy. Design Retrospective case-control study. Setting University-based IVF program. Patient(s) Fifty-five IVF pregnancies and 55 control cycles matched by age, type of infertility, E 2 at ovulation induction, number of oocytes retrieved, and number of embryos replaced. Intervention(s) None. Main outcome measure(s) Association between serum inhibin B at stimulation day 1 (SD1) and OPU and pregnancy; correlation between inhibin B with clinical and endocrine parameters; predictive accuracy of inhibin B measurements at OPU. Result(s) Inhibin B on SD1 was similar between pregnant and nonpregnant subjects, whereas it was significantly higher at OPU in pregnant cycles, but did not allow differentiation between pregnancy outcomes. Inhibin B on SD1 was positively correlated with same-day E 2 in both groups and inversely with age in pregnant cycles. In both groups, inhibin B at OPU correlated positively with number of oocytes collected and with E 2 at ovulation induction. Conclusion(s) Higher inhibin B concentrations at OPU are predictive of clinical pregnancy, independently of age, peak E 2 , number of oocytes retrieved and number of embryos replaced. Inhibin B on stimulation day 1 did not prove to be a useful predictor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|