Quantitative analysis of the amygdala, thalamus and hippocampus on magnetic resonance images in paediatric bipolar disorders and compared with the children of bipolar parents and healthy control
| Autor: | Bunyamin Sahin, Gökhan Sarısoy, Mennan Ece Pirzirenli, Mert Nahir, Meltem Ceyhan, Cihat Dündar, Seher Akbaş |
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| Přispěvatelé: | Ondokuz Mayıs Üniversitesi |
| Rok vydání: | 2017 |
| Předmět: |
Male
Parents medicine.medical_specialty Bipolar Disorder Adolescent Thalamus Neuroscience (miscellaneous) Hippocampus Neuroimaging Audiology Amygdala 03 medical and health sciences Magnetic resonance imaging 0302 clinical medicine medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Bipolar disorder Child Paediatric bipolar disorder medicine.diagnostic_test 05 social sciences Brain Organ Size medicine.disease Magnetic Resonance Imaging 030227 psychiatry Affect Psychiatry and Mental health Mood medicine.anatomical_structure nervous system Case-Control Studies Brain size Female Psychology Neuroscience 050104 developmental & child psychology |
| Zdroj: | Psychiatry Research: Neuroimaging. 270:61-67 |
| ISSN: | 0925-4927 |
| Popis: | Sahin, Bunyamin/0000-0001-8538-8443; Dundar, Cihad/0000-0001-9658-2540 WOS: 000414208800008 PubMed: 29065344 MR imaging studies in paediatric bipolar disorder have particularly focused on the amygdala and hippocampus, subcortical structures, and to a lesser extent on the thalamus. The purpose of this study was to perform structural analysis of the regions of interest (ROI) associated with mood regulation. In this study 18 children (between the ages of 12-18) were matched according to their age and sex and were divided into three groups. These were: a paediatric bipolar disorder group, risk group and a healthy control group. The structured diagnostic interviews were performed with children and their parents. T1 weighted MR images in the sagittal plane with a thickness of 1mm were taken from the subjects. Automatic structural brain analysis was performed, and the volume and volume fraction (VF) of the ROIs were obtained. Brain size in the patients with paediatric bipolar disorder(742.4 +/- 110.1 cm(3)) was significantly smaller than the healthy control group (880.7 +/- 73 .8 cm (3)) (p |
| Databáze: | OpenAIRE |
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