How Comorbidity Reflects on Cerebrospinal Fluid Biomarkers of Neurodegeneration in Aging
| Autor: | Giulia Maria Sancesario, Nicola Biagio Mercuri, Henri Zenuni, Piergiorgio Grillo, Sergio Bernardini, Tommaso Schirinzi |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Short Communication medicine.disease_cause Neuroprotection 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Cerebrospinal fluid biomarkers Internal medicine mental disorders medicine oxidative stress Dementia Neurogranin business.industry General Neuroscience Neurodegeneration neurodegeneration medicine.disease Comorbidity comorbidity Psychiatry and Mental health Clinical Psychology 030104 developmental biology neuroprotection Geriatrics and Gerontology business 030217 neurology & neurosurgery Comorbidity index Oxidative stress |
| Zdroj: | Journal of Alzheimer's Disease Reports |
| ISSN: | 2542-4823 |
| Popis: | Systemic comorbidity precipitates the risk for dementia. To comprehend the underlying mechanisms into a therapeutic perspective, we analyzed how comorbidity affects neurodegeneration-related cerebrospinal fluid (CSF) biomarkers of 55 cognitively intact subjects. The Charson Comorbidity Index (CCI) was correlated with CSF amyloid-β42 (Aβ42), amyloid-β40, total-tau, 181-phosphorylated-tau (p-tau), the Aβ42/p-tau ratio, neurogranin, and lactate. The age-related brain lesions at imaging were also considered. CCI had a raw association with Aβ42/p-tau and p-tau, and a stronger, age-independent correlation with lactate. These preliminary findings suggested that, in normal subjects, systemic comorbidity might increase CNS oxidative stress and, together with aging, contribute to develop an Alzheimer’s disease-like biochemical profile. |
| Databáze: | OpenAIRE |
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