Brain Cortical Complexity Alteration in Amyotrophic Lateral Sclerosis: A Preliminary Fractal Dimensionality Study
| Autor: | Jian-Hua Chen, Tian-Xiu Zou, Hua-Jun Chen, Nao-Xin Huang |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Article Subject Patients General Biochemistry Genetics and Molecular Biology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Text mining Disease severity Internal medicine medicine Humans Amyotrophic lateral sclerosis Gray Matter Aged Cerebral Cortex General Immunology and Microbiology business.industry Fractal dimensionality Amyotrophic Lateral Sclerosis Brain General Medicine Sulcus Middle Aged medicine.disease Central sulcus Pathophysiology Frontal Lobe medicine.anatomical_structure Fractals Cardiology Medicine Female business Insula 030217 neurology & neurosurgery Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2020 (2020) |
| ISSN: | 2314-6141 |
| Popis: | Objective. Fractal dimensionality (FD) analysis provides a quantitative description of brain structural complexity. The application of FD analysis has provided evidence of amyotrophic lateral sclerosis- (ALS-) related white matter degeneration. This study is aimed at evaluating, for the first time, FD alterations in a gray matter in ALS and determining its association with clinical parameters. Materials and Methods. This study included 22 patients diagnosed with ALS and 20 healthy subjects who underwent high-resolution T1-weighted imaging scanning. Disease severity was assessed using the revised ALS Functional Rating Scale (ALSFRS-R). The duration of symptoms and rate of disease progression were also assessed. The regional FD value was calculated by a computational anatomy toolbox and compared among groups. The relationship between cortical FD values and clinical parameters was evaluated by Spearman correlation analysis. Results. ALS patients showed decreased FD values in the left precentral gyrus and central sulcus, left circular sulcus of insula (superior segment), left cingulate gyrus and sulcus (middle-posterior part), right precentral gyrus, and right postcentral gyrus. The FD values in the right precentral gyrus were positively correlated to ALSFRS-R scores (r=0.44 and P=0.023), whereas negatively correlated to the rate of disease progression (r=−0.41 and P=0.039). Meanwhile, the FD value in the left circular sulcus of the insula (superior segment) was negatively correlated to disease duration (r=−0.51 and P=0.010). Conclusions. Our results suggest an ALS-related reduction in structural complexity involving the gray matter. FD analysis may shed more light on the pathophysiology of ALS. |
| Databáze: | OpenAIRE |
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