Efficacy of micronutrient supplementation on skin aging and seasonal variation: a randomized, placebo-controlled, double-blind study
| Autor: | J M Sainthillier, Philippe Humbert, Rafat Messikh, A. Guichard, S. Mac-Mary, Jean-Paul Ortonne, Kamran Hejazi Kenari, Ahmed Elkhyat, Ferial Fanian, Thomas Lihoreau, Adeline Jeudy |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty skin Randomization winter variation Placebo Skin thickness Skin Aging Visioscan® Double blind study Double-Blind Method Internal medicine Confidence Intervals Medicine Humans Micronutrients Original Research Ultrasonography nutraceuticals business.industry General Medicine high-frequency ultrasound Middle Aged Micronutrient Phototype Confidence interval Surgery Treatment Outcome Clinical Interventions in Aging Dietary Supplements Reviscometer® elasticity Female Seasons Geriatrics and Gerontology oral supplementation relief business |
| Zdroj: | Clinical Interventions in Aging |
| ISSN: | 1178-1998 1176-9092 |
| Popis: | Ferial Fanian,1,2 Sophie Mac-Mary,3 Adeline Jeudy,1,2 Thomas Lihoreau,1,2 Rafat Messikh,1,2 Jean-Paul Ortonne,4 Jean-Marie Sainthillier,3 Ahmed Elkhyat,1,2 Alexandre Guichard,1,2 Kamran Hejazi Kenari,1,2 Philippe Humbert1,2,5,61Center for Studies and Research on the Integument (CERT), Department of Dermatology, University Hospital of Besançon, Besançon, France; 2Clinical Investigation Center, CIC-BT 506, CHRU Besançon, France; 3SKINEXIGENCE, University Hospital of Jean Minjoz, Besançon, France; 4Department of Dermatology, University Hospital of L'archet, Nice, France; 5University of Franche-Comté, Besançon, France; 6INSERM 1098, Structure Fédérative de Recherche, Besançon, FranceBackground: Several studies have confirmed dramatic changes in skin surface parameters during the winter months. Although there are many studies supporting the positive effects of topical treatment, there are no published studies demonstrating the effects of oral supplementation in the prevention of negative skin changes during winter. The purpose of this study was to evaluate the efficacy of an oral micronutrient supplement in preventing the negative effects of winter weather on skin quality using noninvasive biometrologic instruments.Methods: This study included 80 healthy female volunteers aged 35–55 years with phototype II–IV skin. Randomization was balanced. Two tablets of a micronutrient supplement (Perfectil® Platinum) or placebo were administered once daily for 4 months. The volunteers were examined at baseline, after 4 months, and 6 weeks after termination of treatment (month 5.5). The evaluation included skin microrelief by Visioscan® as the main outcome, and the secondary outcomes were results on standard macrophotography, skin tension by Reviscometer®, skin high-frequency ultrasound, and self-assessment.Results: For all pseudoroughness and microrelief indicators, there was a significant increase from baseline to month 4 in the placebo group (P |
| Databáze: | OpenAIRE |
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