The Effect of Metal Imbalances on Scrapie Neurodegeneration
| Autor: | Marta Monzón, A. Salomon, Cristina Acín, Juan José Badiola, Eva Monleón, Virginie Vasseur, J. Y. Cesbron, A. Vargas, Bernhard Ryffel, Paloma Hortells |
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| Přispěvatelé: | Research Centre for Prion Diseases, University of Zaragoza - Universidad de Zaragoza [Zaragoza], Immunologie et Embryologie Moléculaires (IEM), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] (LAPM), Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Prions
Epidemiology Scrapie Biology medicine.disease_cause Prion Proteins Pathogenesis Mice 03 medical and health sciences 0302 clinical medicine medicine Animals [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology 030304 developmental biology Manganese 0303 health sciences General Veterinary General Immunology and Microbiology Neurodegeneration Public Health Environmental and Occupational Health Brain Environmental exposure medicine.disease Animal Feed Diet 3. Good health Infectious Diseases Metals Dietary Supplements Immunology Animal Nutritional Physiological Phenomena Copper deficiency Copper 030217 neurology & neurosurgery Oxidative stress Immunostaining Spongiosis |
| Zdroj: | Zoonoses and Public Health Zoonoses and Public Health, Wiley, 2009, epub ahead of print. ⟨10.1111/j.1863-2378.2009.01230.x⟩ |
| ISSN: | 1863-1959 1863-2378 |
| DOI: | 10.1111/j.1863-2378.2009.01230.x⟩ |
| Popis: | International audience; Summary Environmental exposure to metal appears to enhance susceptibility to Transmissible Spongiform Encephalopathies (TSEs); however, published data are not conclusive. The current study focuses on assessing the effects of copper depletion and/or manganese enhancement in the diet on susceptibility to Scrapie and this disease progression. The degree of spongiosis was the highest in the animals that received a copper- depleted diet. These observations suggest that this diet contributes to the Scrapie lesions and to the worsening of the condition in animals that have been inoculated with Scrapie. The highest intensities of GFAP immunostaining were also associated with the copper- depleted diet. Dietary supplementation with manganese had a negative effect on neuronal counts. In conclusion, this study demonstrates that certain environmental factors may aggravate neuropathological Scrapie lesions. This is consistent with reports from other neurodegenerative diseases where some metalloenzymes play a pivotal protector role against the oxidative stress associated with pathogenesis. |
| Databáze: | OpenAIRE |
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