Structure of the RBD-PRDI fragment of the antiterminator protein GlcT
| Autor: | Sebastian Himmel, Sebastian Wolff, Claudia Schwiegk, Stefan Becker, Christian Grosse |
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| Rok vydání: | 2012 |
| Předmět: |
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Molecular Molecular Sequence Data Biophysics Sequence alignment RNA-binding protein Bacillus subtilis Biochemistry 03 medical and health sciences Bacterial Proteins Structural Biology Transcription (biology) Genetics Structural Communications Amino Acid Sequence Protein Structure Quaternary Peptide sequence 030304 developmental biology 0303 health sciences biology 030306 microbiology RNA RNA-Binding Proteins Condensed Matter Physics biology.organism_classification Peptide Fragments Protein Structure Tertiary Terminator (genetics) Linker Sequence Alignment Transcription Factors |
| Zdroj: | Acta Crystallographica Sektion F |
| ISSN: | 1744-3091 |
| Popis: | GlcT is a transcriptional antiterminator protein that is involved in regulation of glucose metabolism inBacillus subtilis. Antiterminator proteins bind specific RNA sequences, thus preventing the formation of overlapping terminator stem-loops. The structure of a fragment (residues 3–170) comprising the RNA-binding domain (RBD) and the first regulatory domain (PRDI) of GlcT was solved at 2.0 Å resolution with one molecule in the asymmetric unit. The two domains are connected by a helical linker. Their interface is mostly constituted by hydrophobic interactions. |
| Databáze: | OpenAIRE |
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