Synchrotron X-ray Scattering Study of the Effects of Microtubule-associated-protein (MAP) Tau on Interprotofilament and Intermicrotubule Interactions
| Autor: | Daniel J. Needleman, Donovan Ventimiglia, Cyrus R. Safinya, Mahn Won Kim, Uri Raviv, Myung Chul Choi, Erkan Kiris, Michelle R. Gaylord, Leslie Wilson, Herbert P. Miller, Stuart C. Feinstein |
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| Rok vydání: | 2009 |
| Předmět: |
Gene isoform
0303 health sciences genetic structures Scattering Chemistry Microtubule-associated protein X-ray Wild type Biophysics macromolecular substances Bioinformatics musculoskeletal system Synchrotron eye diseases law.invention 03 medical and health sciences 0302 clinical medicine Microtubule law sense organs 030217 neurology & neurosurgery Intracellular 030304 developmental biology |
| Zdroj: | Biophysical Journal. 96(3):504a-505a |
| ISSN: | 0006-3495 |
| DOI: | 10.1016/j.bpj.2008.12.2601 |
| Popis: | Neuronal microtubules (MTs) are 25 nm protein nanotubes used as tracks for intracellular trafficking of biomolecules, for example, those involved in transmitting signals between neurons. Distinct members of MAP tau isoforms regulate microtubule assembly and stabilization. Altered tau-MT interactions lead to MT depolymerization and tau tangles, which are implicated in a large number of neurodegenerative diseases. We describe our recent findings about the effect of human wild type MAP tau on interprotofilament and intermicrotubule interactions, by using synchrotron small angle x-ray scattering. Supported by DOE DE-FG02-06ER46314, NSF DMR-0503347, NIH GM-59288, NIHI RO1-NS35010 and NS13560. |
| Databáze: | OpenAIRE |
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