Evaluation of a Hanging-Breast PET System for Primary Tumor Visualization in Patients With Stage I-III Breast Cancer: Comparison With Standard PET/CT
| Autor: | Bas B. Koolen, Vincent van der Noort, Jose Ferrer Rebolleda, Jelle Wesseling, Renato A. Valdés Olmos, Marcel P. M. Stokkel, Emiel J. Th. Rutgers, Raúl Sánchez Jurado, Maria del Puig Cozar Santiago, Suzana C Teixeira |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Breast imaging Breast Neoplasms 030218 nuclear medicine & medical imaging 03 medical and health sciences Young Adult 0302 clinical medicine Breast cancer Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography medicine Mammography Humans Radiology Nuclear Medicine and imaging In patient Whole Body Imaging Aged Neoplasm Staging Aged 80 and over PET-CT medicine.diagnostic_test Tumor size business.industry General Medicine Middle Aged medicine.disease Primary tumor Molecular Imaging 030220 oncology & carcinogenesis Female Radiology Radiopharmaceuticals business Primary breast cancer Nuclear medicine |
| Zdroj: | AJR. American journal of roentgenology. 206(6) |
| ISSN: | 1546-3141 |
| Popis: | The purposes of this study were to evaluate the performance of a mammography with molecular imaging PET (MAMMI-PET) system for breast imaging in the hanging-breast position for the visualization of primary breast cancer lesions and to compare this method with whole-body PET/CT.Between March 2011 and March 2014, a prospective evaluation included women with one or more histologically confirmed primary breast cancer lesions (index lesions). After injection of 180-240 MBq of (18)F-FDG, whole-body PET/CT and MAMMI-PET acquisitions were performed, index lesions were scored 0, 1, or 2 for FDG uptake relative to background. Detection and FDG uptake were compared by breast length, maximal tumor diameter, affected breast quadrants, tumor grade, and histologic and immunologic sub-types. Finally, the two PET modalities were compared for detection of index lesions.For 234 index lesions (diameter, 5-170 mm), the overall sensitivity was 88.9% for MAMMI-PET and 91% for PET/CT (p = 0.61). Twenty-three (9.8%) index lesions located too close to the pectoral muscle were missed with MAMMI-PET, and 20 index lesions were missed with PET/CT. Lesion visibility on MAMMI-PET images was influenced by tumor grade (p = 0.034) but not by cancer subtype (p = 0.65).Although in an overall evaluation MAMMI-PET was not superior to PET/CT, MAMMI-PET does have higher sensitivity for primary breast cancer lesions within the scanning range of the device. Optimization of the positioning device may increase visualization of the most dorsal lesions. |
| Databáze: | OpenAIRE |
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