Polycystic ovaries in adolescents and the relationship with menstrual cycle patterns, luteinizing hormone, androgens, and insulin
| Autor: | Marcel H.A van Hooff, Feja J. Voorhorst, R.A. Hirasing, C. Koppenaal, Margriet B.H Kaptein, Joop Schoemaker |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Hirsutism
medicine.medical_specialty Adolescent media_common.quotation_subject Population Biology Pelvis Waist–hip ratio Hyperinsulinism Surveys and Questionnaires Internal medicine Acne Vulgaris Hyperinsulinemia medicine Humans Insulin education Menstrual Cycle Testosterone Menstrual cycle Netherlands Ultrasonography media_common education.field_of_study Hyperandrogenism Obstetrics and Gynecology Luteinizing Hormone medicine.disease Polycystic ovary Endocrinology Reproductive Medicine Androgens cardiovascular system Female Luteinizing hormone Polycystic Ovary Syndrome circulatory and respiratory physiology |
| Zdroj: | Fertility and Sterility. 74:49-58 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(00)00584-7 |
| Popis: | Study Objective: To evaluate the possible role of inappropriate LH secretion, hyperandrogenism, and hyperinsulinemia in the development of polycystic ovaries (PCO) and the polycystic ovary syndrome. Design: Observational. Setting: General population samples. Participants: 58 adolescents with regular menstrual cycles, 50 with irregular menstrual cycles, and 29 with oligomenorrhea (age 16.7 ± 0.9 years). Interventions: Transabdominal pelvic ultrasonography and vena puncture. Main Outcome Measures: PCO; LH, androstenedione, and testosterone levels; overnight fasting insulin concentrations; and oligomenorrhea. Results: The prevalence of PCO increased significantly with the irregularity of the menstrual cycle pattern, as illustrated by the study, finding PCO in 9% of the girls with regular menstrual cycles, 28% of those with irregular menstrual cycles, and 45% of oligomenorrheic girls. The LH and androgen concentrations were significantly higher in girls with PCO; the insulin levels and the glucose–insulin ratio did not differ when the girls with PCO were compared with girls with normal ovaries. Oligomenorrheic girls with PCO had the highest androgen and LH concentrations; their insulin concentrations and glucose–insulin ratio were in the same range as girls with regular menstrual cycles and normal ovaries; and both their hip and waist girths were wider, although their waist–hip ratio was normal. Conclusions: PCO in adolescents is associated with irregular menstrual cycles, oligomenorrhea, and/or high androgen and LH levels; but no relationship was found with the insulin level or glucose–insulin ratio. Thus, it is doubtful that hyperinsulinemia is an important factor in the development of PCO or polycystic ovary syndrome. |
| Databáze: | OpenAIRE |
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