The migration of metastatic breast cancer cells is regulated by matrix stiffness via YAP signalling
| Autor: | Yuxin Bai, Chrishma Patel, Shihyun Park, Lidan You, Arjun Raha, Wei Chen, Karim Henary, Saeed Mohammadi, Fei Geng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
animal structures Matrix stiffness Matrix (biology) Focal adhesion 03 medical and health sciences 0302 clinical medicine Breast cancer Downregulation and upregulation Mechanosensing medicine lcsh:Social sciences (General) lcsh:Science (General) skin and connective tissue diseases Multidisciplinary Chemistry Stiffness medicine.disease Metastatic breast cancer Cell mobility 030104 developmental biology Cancer research Mechanosensitive channels lcsh:H1-99 YAP medicine.symptom 030217 neurology & neurosurgery Nuclear localization sequence lcsh:Q1-390 Research Article |
| Zdroj: | Heliyon Heliyon, Vol 7, Iss 2, Pp e06252-(2021) |
| ISSN: | 2405-8440 |
| Popis: | Matrix stiffness is a driver of breast cancer progression and mechanosensitive transcriptional activator YAP plays an important role in this process. However, the interplay between breast cancer and matrix stiffness, and the significance of this interplay remained largely unknown. Here, we showed an increase in YAP nuclear localization and a higher proliferation rate in both highly metastatic MDA-MB-231 cells and the non-metastatic counterpart MCF-7 cells when they were exposed to the stiff matrix. However, in response to the stiff matrix highly metastatic MDA-MB-231 cells instead of MCF-7 cells exhibited upregulated mobility, which was shown to be YAP-dependent. Consistently, MDA-MB-231 cells exhibited different focal adhesion dynamics from MCF-7 cells in response to matrix stiffness. These results suggested a YAP-dependent mechanism through which matrix stiffness regulates the migratory potential of metastatic breast cancer cells. Cell mobility; Matrix stiffness; Mechanosensing; Metastatic breast cancer; YAP |
| Databáze: | OpenAIRE |
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