Fibroblast activation protein in liver fibrosis
| Autor: | Hui Emma Zhang, Angelina J. Lay, Geoffrey W. McCaughan, Mark D. Gorrell |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Liver Cirrhosis
0301 basic medicine congenital hereditary and neonatal diseases and abnormalities Anti-Inflammatory Agents Gene Expression Dipeptidyl peptidase Hepatitis 03 medical and health sciences 0302 clinical medicine Fibroblast activation protein alpha Endopeptidases Gene expression Hepatic Stellate Cells Animals Humans Gene family Medicine Molecular Targeted Therapy neoplasms Gene Serine protease chemistry.chemical_classification biology business.industry Serine Endopeptidases Membrane Proteins digestive system diseases Endopeptidase 030104 developmental biology Enzyme chemistry Gelatinases 030220 oncology & carcinogenesis biology.protein Cancer research business Biomarkers |
| Zdroj: | Frontiers in Bioscience. 24:1-17 |
| ISSN: | 1093-4715 1093-9946 |
| Popis: | Fibroblast activation protein (FAP) belongs to the dipeptidyl peptidase IV (DPP4; CD26) gene family. Other related genes in this family of enzyme include DPP4, 8 and 9. The FAP serine protease has the rare property of both dipeptidyl peptidase and endopeptidase activities capable of cleaving the post-proline bond at two or more residues from the N-terminus. FAP is involved in a variety of biological processes but its expression in healthy tissues is low. In contrast, FAP is significantly elevated in pathological conditions such as at sites of tissue remodelling and repair. Its differential pattern of expression in diseases supports the emerging concept for FAP as a potential disease biomarker as well as a useful therapeutic target for drug intervention. This review summarizes the current knowledge of FAP, particularly its diagnostic and pathological significance in liver fibrosis. |
| Databáze: | OpenAIRE |
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