Kidney injury after sodium phosphate solution beyond the acute renal failure
| Autor: | Javier Villacorta, Ramiro Cazar, Carmen Guerrero, Gema Fernández-Juárez, Leticia Parejo, Eduardo Gallego, Isabel Martinez Marin, Katia López, Angel Mendez-Abreu, Tato A, Javier Ocaña, Enrique Gruss |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Calcium Phosphates
Male medicine.medical_treatment 030232 urology & nephrology Colonoscopy Screening colonoscopy lcsh:RC870-923 urologic and male genital diseases chemistry.chemical_compound 0302 clinical medicine Drug Interactions Phosphate nephropathy Insuficiencia renal crónica Aged 80 and over medicine.diagnostic_test Cathartics Renal damage Acute kidney injury Acute Kidney Injury Middle Aged Nephrology Creatinine Female 030211 gastroenterology & hepatology Renal biopsy Hemodialysis Glomerular Filtration Rate medicine.drug medicine.medical_specialty Renal failure Urology Renal function Nefropatía Phosphates Nephropathy 03 medical and health sciences medicine Chronic renal failure Humans Bowel cleansing Renal Insufficiency Chronic Oral sodium Antihypertensive Agents Aged business.industry medicine.disease lcsh:Diseases of the genitourinary system. Urology Insuficiencia renal Surgery Cancer incidence chemistry ACE inhibitor business Follow-Up Studies |
| Zdroj: | Nefrología (English Edition), Vol 36, Iss 3, Pp 243-248 (2016) Nefrología, Vol 36, Iss 3, Pp 243-248 (2016) Nefrología (Madrid) v.36 n.3 2016 SciELO España. Revistas Científicas Españolas de Ciencias de la Salud instname |
| ISSN: | 0211-6995 |
| DOI: | 10.1016/j.nefro.2016.02.010 |
| Popis: | Background and objectives Screening colonoscopy with polipectomy reduces colonorectal cancer incidence and mortality. An adequate bowel cleansing is one of the keys to achieving best results with this technique. Oral sodium phosphate solution (OSP) had a widespread use in the 90s decade. Its efficacy was similar to polyethylene glycol (PEG) solution, but with less cost and convenient administration. Series of patients with acute renal failure due to OSP use have been reported. However, large cohorts of patients found no difference in the incidence of renal damage between these two solutions. Methods From 2006 to 2009 we identified twelve cases of phosphate nephropathy after colonoscopy prepared with OSP. All patients were followed up to six months. All patients had received just a single dose. Results We analyzed 12 cases with phosphate nephropathy; three patients debuted with AKI and nine patients had chronic renal injury. Four cases were confirmed with renal biopsy. One patient with AKI needed hemodialysis at diagnosis without subsequent recovery. Two patients (both with chronic damage) fully recovered their previous renal function. The remaining patients (nine) had an average loss of estimated glomerular filtration rate of 24 ml/min/1.73 m2. Conclusions The use of OSP can lead to both acute and chronic renal damage. However, chronic injury was the most common pattern. Both forms of presentation imply a significant and irreversible loss of renal function. Further studies analyzing renal damage secondary to bowel cleaning should consider these two different patterns of injury. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|