Hemi-gland focal low dose rate prostate brachytherapy: An analysis of dosimetric outcomes
| Autor: | Robert Laing, Jennifer Uribe, A. Franklin, Alex Horton, Stephen M. Langley, Santiago Uribe-Lewis |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Organs at Risk medicine.medical_specialty Biopsy medicine.medical_treatment Brachytherapy 030232 urology & nephrology Pilot Projects 03 medical and health sciences Prostate cancer 0302 clinical medicine Urethra Prostate medicine Humans Dosimetry Radiology Nuclear Medicine and imaging Low dose rate Radiometry Aged Retrospective Studies Multi parametric medicine.diagnostic_test business.industry Rectum Prostatic Neoplasms Radiotherapy Dosage Magnetic resonance imaging Hematology Middle Aged medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Feasibility Studies Radiology Nuclear medicine business Prostate brachytherapy |
| Zdroj: | Radiotherapy and Oncology. 121:310-315 |
| ISSN: | 0167-8140 |
| Popis: | Advances in magnetic resonance imaging (MRI) and prostate sampling enable early identification of men with low to intermediate risk prostate cancer who are candidates for focal therapies that minimise side effects. We report dosimetry data from a pilot study evaluating the effectiveness of hemi-gland low dose rate (HG-LDR) brachytherapy as a focal therapy approach to control unilateral localised disease.Twenty-two men underwent HG-LDR brachytherapy. Multi parametric MRI and transperineal template mapping biopsies were used to identify low volume unilateral disease. Whole gland therapy controls (n=120) were retrospectively obtained. All implants were performed with 4D Brachytherapy.Intraoperative and postimplant dosimetry complied with established brachytherapy parameters. Mean (standard deviation) postoperative D90 for the target hemi-gland was 153.8 (11.3) Gy compared to 47.5 (12.7) Gy for the contralateral hemi-gland (P0.001). Mean postoperative V100% was 93.1 (3.9) and 24.6 (10.5) for the target and contralateral hemi-glands respectively (P0.001). Urethra D30 was 150.4 (19.8) Gy and 174.2 (15.0) Gy for hemi-gland and whole gland implants respectively (P0.001). Significantly reduced dose was also observed for rectum and neurovascular bundles.HG-LDR focal brachytherapy is feasible with significant reduction in dose to the contralateral hemi-gland and organs at risk. |
| Databáze: | OpenAIRE |
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