Antibiotic prophylaxis for caesarean section at a Ugandan hospital: a randomised clinical trial evaluating the effect of administration time on the incidence of postoperative infections
| Autor: | Lomangisi D Dlamini, Davidson Ocen, Agnes Wabule, Musa Sekikubo, Charles Kojjo, Janat Tumukunde, Arthur Kwizera |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Adolescent medicine.drug_class medicine.medical_treatment Antibiotics law.invention Young Adult Randomized controlled trial law Pregnancy Obstetrics and Gynaecology medicine Humans Surgical Wound Infection Caesarean section Single-Blind Method Uganda Antibiotic prophylaxis Intensive care medicine Low-income setting business.industry Cesarean Section Ceftriaxone Obstetrics and Gynecology Antibiotic Prophylaxis medicine.disease Surgery Anti-Bacterial Agents Clinical trial Treatment Outcome Female Endometritis business Infection medicine.drug Research Article |
| Zdroj: | BMC Pregnancy and Childbirth |
| ISSN: | 1471-2393 2013-1100 |
| Popis: | Background Prophylactic antibiotics are used to prevent postoperative infections after caesarean section. Studies have suggested that the timing of prophylaxis plays an important role. Over the years, the role of the anaesthesiologist in the administration of prophylactic antibiotics has become prominent. Therefore, there is an increasing need for anaesthesia providers to understand the rationale of antibiotic prophylaxis. We therefore sought to compare the effect of antibiotics prophylaxis within 1 hour before skin incision and after skin incision on the incidence of postoperative infections in patients undergoing caesarean section at Mulago Hospital. Methods We conducted a single-blind randomised clinical trial conducted at Mulago Hospital evaluating 464 patients undergoing emergency caesarean section. Patients were randomly assigned a group number that allocated them to either arm of the study. They received the same prophylactic antibiotic according to their allotment, that is, either within 1 hour before skin incision or after skin incision as per current standards of practice in Mulago Hospital. They were followed up to detect infection up to 10 days postoperatively. The primary outcome was postoperative infection. The data collected were analysed with STATA version 12 using univariate and bivariate analysis. Results The risk of overall postoperative infection was significantly lower when prophylaxis was given within an hour before incision (RR O.77, 95% CI 0.62–0.97). We also found endometritis to be significantly reduced in the pre-incision group (RR 0.62; 95% CI 0.39–0.99; P value 0.036). Conclusions Giving prophylactic antibiotics before skin incision reduces risk of postoperative infection, in particular of endometritis. Trial registration Pan African Clinical Trial Registry PACTR201311000610495. Date of trial registration: 12th August 2013. |
| Databáze: | OpenAIRE |
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