Human Papillomaviruses and genital co-infections in gynaecological outpatients
| Autor: | Emanuela Mancini, Fernanda Chiarini, Alessandra Pierangeli, Anna Marta Degener, Mauro Bucci, Rosita Verteramo, John Osborn, Nicosia R, Guido Antonelli, Ettore Calzolari |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Genotype Chlamydia trachomatis Cervix Uteri Biology Cervical intraepithelial neoplasia lcsh:Infectious and parasitic diseases Young Adult Medical microbiology Vaginal disease Prevalence medicine Humans lcsh:RC109-216 Papillomaviridae Cervix Cervical cancer Ureaplasma Infections Papillomavirus Infections virus diseases Vaginosis Bacterial Chlamydia Infections medicine.disease biology.organism_classification Dermatology female genital diseases and pregnancy complications Cross-Sectional Studies Infectious Diseases medicine.anatomical_structure Immunology Vagina Female Bacterial vaginosis Ureaplasma urealyticum Research Article |
| Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 9, Iss 1, p 16 (2009) |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/1471-2334-9-16 |
| Popis: | Background High grade HPV infections and persistence are the strongest risk factors for cervical cancer. Nevertheless other genital microorganisms may be involved in the progression of HPV associated lesions. Methods Cervical samples were collected to search for human Papillomavirus (HPV), bacteria and yeast infections in gynaecologic outpatients. HPV typing was carried out by PCR and sequencing on cervical brush specimens. Chlamydia trachomatis was identified by strand displacement amplification (SDA) and the other microorganisms were detected by conventional methods. Results In this cross-sectional study on 857 enrolled outpatients, statistical analyses revealed a significant association of HPV with C. trachomatis and Ureaplasma urealyticum (at high density) detection, whereas no correlation was found between HPV infection and bacterial vaginosis, Streptococcus agalactiae, yeasts, Trichomonas vaginalis and U. urealyticum. Mycoplasma hominis was isolated only in a few cases both in HPV positive and negative women and no patient was infected with Neisseria gonorrhoeae. Conclusion Although bacterial vaginosis was not significantly associated with HPV, it was more common among the HPV positive women. A significant association between HPV and C. trachomatis was found and interestingly also with U. urealyticum but only at a high colonization rate. These data suggest that it may be important to screen for the simultaneous presence of different microorganisms which may have synergistic pathological effects. |
| Databáze: | OpenAIRE |
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