Disruption of immune regulation by microbial pathogens and resulting chronic inflammation
| Autor: | Kenneth R. Barth, Daniel G. Remick, Caroline A. Genco |
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| Rok vydání: | 2013 |
| Předmět: |
Cell type
Physiology Clinical Biochemistry Endogeny Inflammation Biology Article Microbiology Mycobacterium tuberculosis Immune system Bacteroidaceae Infections medicine Antigenic variation Humans Tuberculosis Pulmonary Porphyromonas gingivalis Models Immunological Immune regulation Bacterial Infections Cell Biology biology.organism_classification Chronic Disease Host-Pathogen Interactions Immunology medicine.symptom Signal Transduction |
| Zdroj: | Journal of Cellular Physiology. 228:1413-1422 |
| ISSN: | 0021-9541 |
| DOI: | 10.1002/jcp.24299 |
| Popis: | Activation of the immune response is a tightly regulated, coordinated effort that functions to control and eradicate exogenous microorganisms, while also responding to endogenous ligands. Determining the proper balance of inflammation is essential, as chronic inflammation leads to a wide array of host pathologies. Bacterial pathogens can instigate chronic inflammation via an extensive repertoire of evolved evasion strategies that perturb immune regulation. In this review, we discuss two model pathogens, Mycobacterium tuberculosis and Porphyromonas gingivalis, which efficiently escape various aspects of the immune system within professional and non-professional immune cell types to establish chronic inflammation. |
| Databáze: | OpenAIRE |
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