Long-term supplementation with phenolic compounds from jaboticaba (Plinia jaboticaba (Vell.) Berg) reduces adiposophaty and improves glucose, lipid, and energy metabolism
| Autor: | Rafaela Rossi e Silva, Willian T. Festuccia, Maria Inés Genovese, Carlos M. Donado-Pestana, Érika Vicência Monteiro Pessoa, Larissa Rodrigues, Márcio Hercules Caldas Moura |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
030309 nutrition & dietetics
Berry Type 2 diabetes Anthocyanins Mice 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Insulin resistance medicine GLICOSE Animals Food science Gallic acid 0303 health sciences business.industry 04 agricultural and veterinary sciences medicine.disease Lipids 040401 food science Obesity Mice Inbred C57BL Glucose Diabetes Mellitus Type 2 chemistry Polyphenol Dietary Supplements Adipocyte hypertrophy Energy Metabolism business Brazil Food Science Ellagic acid |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0963-9969 |
| DOI: | 10.1016/j.foodres.2021.110302 |
| Popis: | Obesity is a critical public health problem worldwide that has been associated to non-communicable diseases (NCD), such as type 2 diabetes (T2DM), non-alcoholic fatty lipid diseases (NAFLD) and inflammatory diseases. Polyphenols from several food sources have been studied as one option against these health problems. Sabara jaboticaba (Plinia jaboticaba (Vell.) Berg) is a Brazilian berry rich in ellagic acid derivatives and anthocyanins. Here we investigated the effects of a phenolic-rich extract from Sabara jaboticaba (PEJ) in a diet-induced obesity animal model. PEJ at two doses, 50 mg gallic acid equivalent (GAE)/kg body weight (BW) and 100 mg GAE/kg BW, were administered by daily gavage to obese C57BL/6J mice for 14 weeks. PEJ prevented the excessive body weight and adiposity, adipocyte hypertrophy, inflammation, hyperglycemia, glucose intolerance, insulin resistance, hypercholesterolemia, and hepatic lipid accumulation, as well as increased energy expenditure. In conclusion, polyphenols from Sabara jaboticaba presented several powerful therapeutic properties relevant for fighting obesity and associated health problems. |
| Databáze: | OpenAIRE |
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