Soluble E-selectin in multiple sclerosis: raised concentrations in patients with primary progressive disease
| Autor: | Geoffrey Keir, E J Thompson, Desmond Kidd, Gavin Giovannoni, DH Miller, Marc Feldmann, Brian Kendall, Alan J. Thompson, J W Thorpe, I. F. Moseley |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Necrosis Multiple Sclerosis Remission Spontaneous Gastroenterology Central nervous system disease Von Willebrand factor Recurrence Internal medicine E-selectin von Willebrand Factor medicine Humans medicine.diagnostic_test biology business.industry Tumor Necrosis Factor-alpha Multiple sclerosis C-reactive protein Magnetic resonance imaging Middle Aged medicine.disease Prognosis Magnetic Resonance Imaging Psychiatry and Mental health C-Reactive Protein Case-Control Studies biology.protein Surgery Tumor necrosis factor alpha Female Neurology (clinical) medicine.symptom business E-Selectin Biomarkers Research Article |
| Popis: | OBJECTIVE: To determine whether concentrations of soluble E-selectin (sE-selectin), an immunological marker of endothelial activation, were correlated with gadolinium-DPTA enhancement on MRI in patients with multiple sclerosis. METHODS: Serial sE-selectin concentrations were measured in 28 patients with multiple sclerosis undergoing monthly gadolinium (Gd) enhanced MRI of the brain and spinal cord, and in 10 control subjects. C reactive protein (CRP), von Willebrand factor (vWF), and tumour necrosis factor-alpha (TNF alpha) were also determined. RESULTS: Primary progressive patients had significantly increased sE-selectin concentrations compared with the relapsing remitting and secondary progressive patients who had normal sE-selectin concentrations (22.2 (SD1 6.1) ng/ml v 9.8 (SD2.1) ng/ml and 7.7 (SD2.7) ng/ml, respectively, P = 0.03). This difference was attributable to five of the 10 primary progressive patients who had persistently raised sE-selectin concentrations, with relatively inactive MRI studies. No correlation could be found between sE-selectin concentrations and Gd enhancement on MRI, but a close correlation existed between mean concentrations of sE-selectin and TNF alpha (r = 0.71, P < 0.001). Despite raised sE-selectin and TNF alpha concentrations, primary progressive patients had normal CRP concentrations (1.03 (SD1.14) mg/l), which were significantly lower than the relapsing remitting (3.16 (SD2.54) mg/l) and secondary progressive patients (2.28 (SD2.1) mg/l, P = 0.03). Raised CRP concentrations did correlate with infectious episodes, clinical relapse, and Gd enhancement, and were significantly raised when no MRI activity was found. Concentrations of vWF were normal in all patient groups. CONCLUSIONS: The results further high-light the differences between patients with primary progressive and those with relapsing remitting/secondary progressive multiple sclerosis. |
| Databáze: | OpenAIRE |
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