T(1) cortical hypointensities and their association with cognitive disability in multiple sclerosis
| Autor: | Antonio Gallo, Fredric K. Cantor, Clelia Pellicano, Vasiliki N. Ikonomidou, Henry F. McFarland, Mary Ehrmantraut, Susan K. Stern, Robert L. Kane, Francesca Bagnato, Zeena Salman, Joan Ohayon, Sungyoung Auh |
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| Přispěvatelé: | Bagnato, F, Salman, Z, Kane, R, Auh, S, Cantor, Fk, Ehrmantraut, M, Gallo, Antonio, Ikonomidou, Vn, Ohayon, J, Pellicano, C, Stern, Sk, Mcfarland, Hf |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Multiple Sclerosis Image Processing Neuropsychological Tests Central nervous system disease Lesion Disability Evaluation Young Adult Degenerative disease Computer-Assisted T2 lesions medicine Image Processing Computer-Assisted Humans Cerebral Cortex medicine.diagnostic_test Multiple sclerosis Medicine (all) Neuropsychology Magnetic resonance imaging Cognition Middle Aged Verbal Learning medicine.disease Magnetic Resonance Imaging Pathology of multiple sclerosis MRI multiple sclerosis Case-Control Studies Cognition Disorders Female Neurology (clinical) Neurology Radiology medicine.symptom Psychology |
| Popis: | Background: Neocortical lesions (NLs) largely contribute to the pathology of multiple sclerosis (MS), although their relevance in patients’ disability remains unknown. Objective: To assess the incidence of T1 hypointense NLs by 3.0-Tesla magnetic resonance imaging (MRI) in patients with MS and examine neocortical lesion association with cognitive impairment. Methods: In this case-control study, 21 MS patients and 21 age-, sex- and years of education-matched healthy volunteers underwent: (i) a neuropsychological examination rating cognitive impairment (Minimal Assessment of Cognitive Function in MS); (ii) a 3.0-Tesla MRI inclusive of an isotropic 1.0 mm3 three-dimensional inversion prepared spoiled gradient-recalled-echo (3D-IRSPGR) image and T1- and T2-weighted images. Hypointensities on 3D-IRSPGR lying in the cortex, either entirely or partially were counted and association between NLs and cognitive impairment investigated. Results: A total of 95 NLs were observed in 14 (66.7%) patients. NL+ patients performed poorer (p = 0.020) than NLpatients only on the delayed recall component of the California Verbal Learning Test. This difference lost statistical significance when a correction for white matter lesion volume was employed. Conclusions: Although T 1 hypointense NLs may be present in a relatively high proportion of multiple sclerosis patients, the impact that they have in cognitive impairment is not independent from white matter disease. |
| Databáze: | OpenAIRE |
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