Tumor-Infiltrating Lymphocytes/Plasmocytes in Chemotherapeutically Non-Influenced Triple-Negative Breast Cancers - Correlation with Morphological and Clinico-Pathological Parameters
| Autor: | Zdeněk Kolář, Nora Zlamalova, Gabriela Kořínková, Jiří Ehrmann, Bohuslav Melichar, Radek Trojanec, Marketa Koleckova |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Low protein medicine.medical_treatment Triple Negative Breast Neoplasms Breast cancer Lymphocytes Tumor-Infiltrating medicine Humans Lymph node Pathological Neoadjuvant therapy Mastectomy Tumor-infiltrating lymphocytes business.industry Middle Aged medicine.disease Prognosis Neoadjuvant Therapy medicine.anatomical_structure Ki-67 Antigen Oncology Proto-Oncogene Proteins c-bcl-2 Drug Resistance Neoplasm Female Neoplasm Grading business |
| Zdroj: | Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti. 32(5) |
| ISSN: | 1802-5307 |
| Popis: | Background Triple-negative breast cancers (TNBCs) are considered a morphologically heterogeneous group of breast carcinomas characterized by the absence or low protein expression of hormone receptors and HER2/neu/ERBB2 with a specific biological behavior and therapeutic response. This study aimed to evaluate correlations of the density of tumor-infiltrating lymphocytes/plasmocytes (TILs) in the tumor parenchyma, stroma, and invasive margins with tumor morphology, the proliferation rate, Bcl-2 expression, and selected clinical and pathological parameters in early breast cancer patients prior to mastectomy who had not received initial chemotherapy. Materials and methods Samples of 3,544 breast cancer patients investigated in our department between 2007 and 2017 were re-examined. In total, 413 (11.65%) patients were diagnosed with TNBC. Only 61 cases did not undergo neoadjuvant therapy prior to mastectomy. Correlations between the density of TILs and tumor morphology, Bcl-2 expression, proliferative activity measured by Ki-67, patient age at diagnosis, tumor grade, and metastases were investigated. Results The samples were predominantly relatively well-localized invasive carcinomas of no special type with medullary features (80.32%) that measured on average 13.4mm (range 5-20mm, median 15mm) and exhibited central necrosis or fibrosis, a tendency to undergo spindle cell and/or apocrine-like differentiation, and intensive infiltration of TILs. There were significant positive correlations between TILs and premenopausal status (p=0.003), Ki-67 expression (p=0.015), and tumor grade (p=0.002), a marginal positive correlation between TILs and tumor size (p=0.065), and a significant negative correlation between TILs and Bcl-2 expression (p=0.035). In younger patients (l 50 years) with tumor size less than or equal to 20 mm (pT1a-pT1c) we recorded a lower number of women with metastatic lymph node involvement (p=0.001). Conclusion The density and location of TILs in non-therapeutically influenced TNBCs, evaluated in the context of morphological changes and other clinicopathological parameters, may have prognostic significance and assist effective therapy planning. |
| Databáze: | OpenAIRE |
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