The beneficial effects of amineptine (Survector 100) in the treatment of depression: preliminary results of an Indian multicenter trial
| Autor: | Shah Lp, Boral Gc |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male Amineptine India Dibenzocycloheptenes Antidepressive Agents Tricyclic Oral administration Rating scale Heart Rate Multicenter trial Medicine Humans Multicenter Studies as Topic Pharmacology (medical) Adverse effect Depression (differential diagnoses) Pharmacology Depressive Disorder business.industry Middle Aged Clinical trial Anesthesia Female Neurology (clinical) Liver function business medicine.drug |
| Zdroj: | Clinical neuropharmacology. 12 |
| ISSN: | 0362-5664 |
| Popis: | A multicenter study of the efficacy and safety of amineptine in the treatment of depression has been performed in India. Patients fulfilling the DSM-III criteria for depression were included in this open clinical trial and treated with amineptine for 6 weeks. They received one 100-mg tablet or two (100 mg) tablets of amineptine per day. Efficacy of treatment was assessed using the Hamilton Depression Rating scale on D0, D7, D14, D21, D35, and D42. Liver function and cardiovascular function were examined on D0 and D42 to assess possible adverse effect of treatment. The preliminary results in 32 patients showed that amineptine was effective as soon as the 7th day of treatment and that this effect improved continuously throughout the study. Amineptine was found to be safe. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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