Temporally restricted dopaminergic control of reward-conditioned movements
| Autor: | Leslie D. Claar, Jay Gill, Jacquelyn Nguyen, Jeremy M. Trott, Ayaka Hachisuka, Sotiris C. Masmanidis, Kwang Lee, Konstantin I. Bakhurin |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Dopamine Movement Conditioning Classical Substantia nigra Biology Optogenetics Midbrain Mice 03 medical and health sciences 0302 clinical medicine Reward Mesencephalon medicine Animals Behavior Animal Pars compacta Dopaminergic Neurons General Neuroscience Dopaminergic Classical conditioning Mice Inbred C57BL Ventral tegmental area 030104 developmental biology medicine.anatomical_structure nervous system Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Nature Neuroscience. 23:209-216 |
| ISSN: | 1546-1726 1097-6256 |
| Popis: | Midbrain dopamine (DA) neurons encode both reward- and movement-related events and are implicated in disorders of reward processing as well as movement. Consequently, disentangling the contribution of DA neurons in reinforcing versus generating movements is challenging and has led to lasting controversy. In this study, we dissociated these functions by parametrically varying the timing of optogenetic manipulations in a Pavlovian conditioning task and examining the influence on anticipatory licking before reward delivery. Inhibiting both ventral tegmental area and substantia nigra pars compacta DA neurons in the post-reward period had a significantly greater behavioral effect than inhibition in the pre-reward period of the task. Furthermore, the contribution of DA neurons to behavior decreased linearly as a function of elapsed time after reward. Together, the results indicate a temporally restricted role of DA neurons primarily related to reinforcing stimulus-reward associations and suggest that directly generating movements is a comparatively less important function. |
| Databáze: | OpenAIRE |
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