Critical Review of Tricyclic Antidepressant Use in Children and Adolescents
| Autor: | Henrietta L. Leonard, Barbara Geller, B. Timothy Walsh, Mark A. Riddle, Daniel Reising |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Child Psychiatry
Research design Clinical Trials as Topic Depressive Disorder medicine.medical_specialty Adolescent medicine.drug_class MEDLINE Tricyclic antidepressant Sudden unexplained death Antidepressive Agents Tricyclic Psychiatry and Mental health Adolescent Psychiatry Research Design Unresolved Issue Epidemiology Developmental and Educational Psychology medicine Humans Child Psychology Psychiatry |
| Zdroj: | Journal of the American Academy of Child & Adolescent Psychiatry. 38:513-516 |
| ISSN: | 0890-8567 |
| DOI: | 10.1097/00004583-199905000-00012 |
| Popis: | Objectives To provide a critical review of the role of tricyclic antidepressant (TCA) medications in children and adolescents. Method Multiple resources including a Medline search (1966–1998) were used. Results: There were few double-blind, placebo-controlled studies of TCAs, and even fewer with positive results. Also, potentially serious cardiovascular side effects have been described. Conclusion The future therapeutic role of TCAs for children and adolescents needs to be seriously weighed against lethality of overdose, the unresolved issue of possible sudden unexplained death, and the availability of safer and easier to monitor medications. Ongoing future research on heart rate variability and epidemiology of psychotropic medication-related deaths will address developmental aspects of TCA use. |
| Databáze: | OpenAIRE |
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