Anti-glutamic acid decarboxylase antibody (GAD) syndromes may have more aggressive disease course in African Americans and early onset of presentation compare to Caucasians group
| Autor: | Meghana Srinivas, Abbas Jowkar, Anila Kanna, Shitiz Sriwastava, Edwin George, Kalyan Yarraguntla |
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| Rok vydání: | 2019 |
| Předmět: |
lcsh:RC346-429
03 medical and health sciences 0302 clinical medicine Autoimmune Process Stiff person syndrome Refractory seizure medicine 030212 general & internal medicine Autoimmune epilepsy lcsh:Neurology. Diseases of the nervous system Autoimmune encephalitis Cerebellar ataxia biology business.industry Incidence (epidemiology) Limbic encephalitis medicine.disease Neurology Cohort Immunology biology.protein Original Article medicine.symptom Antibody business 030217 neurology & neurosurgery |
| Zdroj: | eNeurologicalSci eNeurologicalSci, Vol 17, Iss, Pp-(2019) |
| ISSN: | 2405-6502 |
| Popis: | Anti-Glutamic acid decarboxylase antibodies (GAD) are increasingly diagnosed in the clinic and this antibody related syndromes can manifest commonly as autoimmune encephalitis, Stiff person syndrome and cerebellar ataxia. However, it is unclear if the race has role in age of incidence, presentation and severity of symptoms of anti-GAD associated conditions. In our cohort of 40 patients who were anti-GAD positive, we observed that the age at which the anti-GAD titers turned out to be positive was significantly lower in African Americans (AA) compared to Caucasians (Cau) irrespective of the type of conditions. However, the age at symptoms onset didn't differ significantly different between these groups. Furthermore, AA anti-GAD positive patients had seizures as their initial presentation that was significantly higher in incidence compared to Cau indicating that AA have more aggressive form of autoimmune phenomenon for reasons unknown. Future studies to explore the variations in autoimmune process and their phenotypes may aid in understanding anti-GAD syndromes differently between these racial groups. Keywords: Stiff person syndrome, Limbic encephalitis, Autoimmune epilepsy, Refractory seizure |
| Databáze: | OpenAIRE |
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