Interfacial fluid transport is a key to hydrogel bioadhesion
| Autor: | Quentin van Poelvoorde, Raphael Michel, Laurent Corté, Mathieu Manassero, Léna Poirier, Josette Legagneux |
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| Přispěvatelé: | Centre des Matériaux (MAT), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Chimie Moléculaire, Macromoléculaire et Matériaux (UMR7167) (C3M), Centre National de la Recherche Scientifique (CNRS)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC), École nationale vétérinaire d'Alfort (ENVA), Laboratoire Matière Molle et Chimie (MMC), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Swine Bioadhesive Organism Hydration Status 02 engineering and technology 010402 general chemistry 01 natural sciences Parenchyma Tissue hydration [CHIM]Chemical Sciences Animals ComputingMilieux_MISCELLANEOUS [PHYS]Physics [physics] Multidisciplinary Dehydration Adhesiveness Hydrogels Adhesion 021001 nanoscience & nanotechnology Fluid transport 0104 chemical sciences Liver Self-healing hydrogels Physical Sciences Biophysics Tissue Adhesives Adhesive 0210 nano-technology Ex vivo |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (3), pp.738-743. ⟨10.1073/pnas.1813208116⟩ |
| ISSN: | 0027-8424 1091-6490 |
| Popis: | Attaching hydrogels to soft internal tissues is a key to the development of a number of biomedical devices. Nevertheless, the wet nature of hydrogels and tissues renders this adhesion most difficult to achieve and control. Here, we show that the transport of fluids across hydrogel−tissue interfaces plays a central role in adhesion. Using ex vivo peeling experiments on porcine liver, we characterized the adhesion between model hydrogel membranes and the liver capsule and parenchyma. By varying the contact time, the tissue hydration, and the swelling ratio of the hydrogel membrane, a transition between two peeling regimes is found: a lubricated regime where a liquid layer wets the interface, yielding low adhesion energies (0.1 J/m(2) to 1 J/m(2)), and an adhesive regime with a solid binding between hydrogel and tissues and higher adhesion energies (1 J/m(2) to 10 J/m(2)). We show that this transition corresponds to a draining of the interface inducing a local dehydration of the tissues, which become intrinsically adhesive. A simple model taking into account the microanatomy of tissues captures the transition for both the liver capsule and parenchyma. In vivo experiments demonstrate that this effect still holds on actively hydrated tissues like the liver capsule and show that adhesion can be strongly enhanced when using superabsorbent hydrogel meshes. These results shed light on the design of predictive bioadhesion tests as well as on the development of improved bioadhesive strategies exploiting interfacial fluid transport. |
| Databáze: | OpenAIRE |
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