Effect of Autologous Fibrin Glue on Seroma Reduction after Modified Radical Mastectomy for Breast Cancer: A Randomized Controlled Trial
| Autor: | Sara Salem, Noha Kamel, Hamada Fathy, Mohammed Faisal, Ahmed Abo Bakr, Haidi Abd-Elzaher |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Breast surgery medicine.medical_treatment Modified Radical Mastectomy law.invention 03 medical and health sciences 0302 clinical medicine Breast cancer Randomized controlled trial law medicine Fibrin glue Radical mastectomy Original Research business.industry Cancer General Medicine medicine.disease Surgery Seroma 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology business Autologous |
| Zdroj: | Annals of Medicine and Surgery |
| Popis: | Introduction Breast cancer stands out as the second most common cancer in the world with incidence 35.1% of all malignancies among females in Egypt. Fluid build-up after breast surgery is still the most annoying complication which leads to worse outcome. We aimed to evaluate whether autologous fibrin glue might lessen the formation of seroma following modified radical mastectomy. Methods This was a randomized controlled trial designed to configure the effect of autologous fibrin glue given in the study group using the drain in comparison to a control group who received the drain only; seroma volume was calculated every 24 h. For all of the cases. The drains were removed when the daily drainage was less than 30 ml for 3 consecutive days. Results We recruited 30 patients to each of the two groups. Age, pathology, breast cancer stage, number of lymph nodes and tumour size did not differ significantly between groups. A comparison of the median days to drain removal showed 8 days reduction in median days to drain removal compared in the intervention group (7 days) than the control (15 days). The patients in the fibrin glue group had a significantly lower cumulative drain output volume (mean ± SD of 505,6 ± 209,3 ml) than those in the control group (1674.1 ± 1 373,8 ml). Conclusions Autologous fibrin glue significantly decrease seroma formation post-modified radical mastectomy. Highlights • Seroma is the most annoying complication after breast cancer surgery. • Fibrin glue is an adhesive agent has been associated with reduction in the fluid build-up post mastectomy. • Autologous Fibrin Glue is easily prepared and safe agent. • The usage of Autologous fibrin glue help in short hospital stay after mastectomy. • This is the first randomized clinical intervention to use fibrin glue from autologous nature to reduce seroma formation after MRM. |
| Databáze: | OpenAIRE |
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