Pharmacological concentrations of biotin reduce serum triglycerides and the expression of lipogenic genes
| Autor: | Elena Larrieta, Alberto Gómez Tagle Rojas, Cristina Fernandez-Mejia, Fidel Velasco, María Luisa Lazo-de-la-Vega-Monroy, Teresita López-Aceves, Paz Vital |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Biotin Adipose tissue Biology Mice chemistry.chemical_compound Insulin resistance Internal medicine medicine Animals Insulin RNA Messenger Triglycerides Pharmacology Mice Inbred BALB C Glucokinase Lipogenesis Glucose Tolerance Test medicine.disease Pyruvate carboxylase Fatty acid synthase Endocrinology Adipose Tissue Gene Expression Regulation Liver chemistry Vitamin B Complex biology.protein Insulin Resistance |
| Zdroj: | European Journal of Pharmacology. 644:263-268 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2010.07.009 |
| Popis: | Besides its role as a carboxylase prosthetic group, biotin regulates gene expression and has a wide repertoire of effects on systemic processes. Several studies have shown that pharmacological concentrations of biotin reduce hypertriglyceridemia. The molecular mechanisms by which pharmacological concentrations of biotin affect lipid metabolism are largely unknown. The present study analyzed the effects of pharmacological doses of biotin on triglyceridemia, insulin sensitivity and on mRNA expression of various lipogenic genes. Three-week-old male BALB/cAnN Hsd mice were fed a biotin-control or a biotin-supplemented diet (1.76 or 97.7mg of free biotin/kg diet, respectively) over a period of eight weeks. Serum triglyceride concentrations, insulin and glucose tolerance and mRNA abundance of various lipogenic genes were investigated. The biotin-supplemented group showed 35% less serum triglycerides than control mice. In the liver, we found a significant (P |
| Databáze: | OpenAIRE |
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