An extremely aggressive case of Marburg's disease treated with high dose cyclophosphamide. A case report
| Autor: | Carmen Serrano, Gishlaine Alfonso, Franchesca Fiorito, Eduardo J. Labat, Jose Avila-Ornelas |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Multiple Sclerosis Neurology Cyclophosphamide Fulminant Disease Young Adult 03 medical and health sciences 0302 clinical medicine Refractory medicine Humans 030212 general & internal medicine Marburg's variant multiple sclerosis Plasma Exchange business.industry Multiple sclerosis Brain General Medicine medicine.disease Treatment Outcome Hemiparesis Female Neurology (clinical) medicine.symptom business Immunosuppressive Agents 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Multiple Sclerosis and Related Disorders. 31:51-53 |
| ISSN: | 2211-0348 |
| DOI: | 10.1016/j.msard.2019.03.014 |
| Popis: | Background The acute, fulminant type of Multiple Sclerosis (MS), known as Marburg Disease, has been shown to have poor response to conventional acute treatments typically used for demyelinating diseases. Methods We report a 20 y/o postpartum female who was consulted to the Neurology service given findings of subacute left sided hemiparesis, left homonymous hemianopsia and bilateral papilledema. Extensive workup, including Brain and Cervical spine MRI with and without gadolinium, blood work, CSF studies, in addition to her rapid clinical decline, were highly suggestive of the demyelinating variant of Multiple Sclerosis known as Marburg Disease. After excluding other possible diagnosis, she was treated with IV corticosteroids and plasma exchange therapy with poor response. She was then started on monthly high dose cyclophosphamide therapy. Results Clinical and radiological improvement was present with initiation of cyclophosphamide therapy in this refractory variant of MS. Conclusion Our findings suggest that cyclophosphamide may be a therapeutic alternative to induce clinical and radiological improvement in Marburg Disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect