Insulin-like growth factor (IGF) parameters and tools for efficacy: the IGF-I generation test in children
| Autor: | Ron G. Rosenfeld, Jaime Guevara-Aguirre, Caroline K. Buckway, Karin A. Selva, K. L. Pratt |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Growth hormone receptor Biology medicine.disease_cause Insulin-like growth factor-binding protein Growth hormone deficiency Insulin-like growth factor Basal (phylogenetics) Endocrinology Internal medicine medicine Humans Insulin-Like Growth Factor I Child Mutation Human Growth Hormone Growth factor Reproducibility of Results medicine.disease Body Height Idiopathic short stature Insulin-Like Growth Factor Binding Protein 3 Pediatrics Perinatology and Child Health biology.protein |
| Zdroj: | Hormone research. 62 |
| ISSN: | 0301-0163 |
| Popis: | Serum levels of growth hormone (GH)-dependent peptides could provide important and valuable measures of GH sensitivity and, potentially, responsiveness. In normal individuals, serum insulin-like growth factor I (IGF-I) concentrations are dependent on the dose of GH given, with IGF-I responsiveness not decreasing with age. Individuals heterozygous for the E180 GH receptor (GHR) splice mutation have normal IGF-I generation, but those homozygous for the E180 splice mutation have very low basal and stimulated IGF-I concentrations. Similar results are observed for the serum IGF-binding protein 3 (IGFBP-3) response to GH, with a correlation between changes in serum concentrations of IGF-I and changes in IGFBP-3 in normal, heterozygotic, GH-insensitive and GH-deficient participants. In individuals with the E180 splice mutation, IGF-I and IGFBP-3 tests show sensitivity and specificity for detecting GH insensitivity (GHI). In children with idiopathic short stature, it appears that some individuals have selective resistance to GH, with their ability to generate IGF-I more impaired than their ability to generate other GH-dependent peptides. This heterogeneous group may require individualization of GH dosage. IGF generation tests remain the best short-term, in vivo test for classic GHI, although diagnostic tests will undoubtedly require further modification to identify milder pathophysiologic abnormalities. |
| Databáze: | OpenAIRE |
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