Influence of vascular endothelial growth factor single nucleotide polymorphisms on tumour development in cutaneous malignant melanoma
| Autor: | J. M. Theaker, Andrew Collins, Adrian C Bateman, W. M. Howell, S J Turner |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Vascular Endothelial Growth Factor A
Linkage disequilibrium Skin Neoplasms Immunology Single-nucleotide polymorphism Endothelial Growth Factors Biology Polymorphism Single Nucleotide Linkage Disequilibrium chemistry.chemical_compound Vasculogenesis Genotype Genetics medicine Humans SNP Melanoma Genetics (clinical) Lymphokines Vascular Endothelial Growth Factors Haplotype medicine.disease Survival Analysis Vascular endothelial growth factor Haplotypes chemistry Cancer research Intercellular Signaling Peptides and Proteins |
| Zdroj: | Genes & Immunity. 3:229-232 |
| ISSN: | 1476-5470 1466-4879 |
| DOI: | 10.1038/sj.gene.6363851 |
| Popis: | Vascular endothelial growth factor (VEGF) is a potent regulator of vasculogenesis and tumour angiogenesis. We have investigated whether the VEGF -2578, -1154, +405 and +936 SNPs and associated haplotypes confer susceptibility to and/or influence prognosis in cutaneous malignant melanoma (CMM) skin cancer. A total of 152 CMM patients and 266 controls were genotyped for VEGF promoter SNPs by ARMS-PCR. Strong linkage disequilibrium between the -2578, -1154 and +405 SNPs was detected (association, rho = 0.488-0.965), but not between these SNPs and SNP +936 (association, rho = 0.004-0.130). No SNPs or three SNP haplotypes (-2578, -1154, +405) were significantly associated with CMM, although a number of non-significant trends were observed. However, the VEGF -1154 AA genotype and -2578, -1154, +405 CAC haplotype were both significantly associated with less advanced (Stage 1) disease (P = 0.03). In addition, the VEGF -1154 AA genotype was associated with thinner primary vertical growth phase tumours (P = 0.002), while VEGF -1154 GG was associated with thicker primary tumours (P = 0.02). These preliminary results indicate that VEGF genotype may influence tumour growth in CMM, possibly via the effects of differential VEGF expression on tumour angiogenesis. |
| Databáze: | OpenAIRE |
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