Computed Tomography Aortic Valve Calcium Scoring in Patients With Aortic Stenosis
| Autor: | Tania Pawade, Marie-Annick Clavel, Christophe Tribouilloy, Julien Dreyfus, Tiffany Mathieu, Lionel Tastet, Cedric Renard, Mesut Gun, William Steven Arthur Jenkins, Laurent Macron, Jacob W. Sechrist, Joan M. Lacomis, Virginia Nguyen, Laura Galian Gay, Hug Cuéllar Calabria, Ioannis Ntalas, Timothy Robert Graham Cartlidge, Bernard Prendergast, Ronak Rajani, Arturo Evangelista, João L. Cavalcante, David E. Newby, Philippe Pibarot, David Messika Zeitoun, Marc R. Dweck |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Aortic valve medicine.medical_specialty 030204 cardiovascular system & hematology Severity of Illness Index 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Aortic valve replacement Internal medicine Multidetector Computed Tomography Severity of illness medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Registries Prospective cohort study Aged Aged 80 and over business.industry Hazard ratio Calcinosis Aortic Valve Stenosis Prognosis medicine.disease Echocardiography Doppler Confidence interval Stenosis medicine.anatomical_structure Aortic Valve Heart Valve Prosthesis Aortic valve stenosis Cardiology Calcium Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation: Cardiovascular Imaging. 11 |
| ISSN: | 1942-0080 1941-9651 |
| DOI: | 10.1161/circimaging.117.007146 |
| Popis: | Background— Computed tomography aortic valve calcium scoring (CT-AVC) holds promise for the assessment of patients with aortic stenosis (AS). We sought to establish the clinical utility of CT-AVC in an international multicenter cohort of patients. Methods and Results— Patients with AS who underwent ECG-gated CT-AVC within 3 months of echocardiography were entered into an international, multicenter, observational registry. Optimal CT-AVC thresholds for diagnosing severe AS were determined in patients with concordant echocardiographic assessments, before being used to arbitrate disease severity in those with discordant measurements. In patients with long-term follow-up, we assessed whether CT-AVC thresholds predicted aortic valve replacement and death. In 918 patients from 8 centers (age, 77±10 years; 60% men; peak velocity, 3.88±0.90 m/s), 708 (77%) patients had concordant echocardiographic assessments, in whom CT-AVC provided excellent discrimination for severe AS (C statistic: women 0.92, men 0.89). Our optimal sex-specific CT-AVC thresholds (women 1377 Agatston unit and men 2062 Agatston unit) were nearly identical to those previously reported (women 1274 Agatston unit and men 2065 Agatston unit). Clinical outcomes were available in 215 patients (follow-up 1029 [126–2251] days). Sex-specific CT-AVC thresholds independently predicted aortic valve replacement and death (hazard ratio, 3.90 [95% confidence interval, 2.19–6.78]; P P =0.010). Conclusions— Sex-specific CT-AVC thresholds accurately identify severe AS and provide powerful prognostic information. These findings support their integration into routine clinical practice. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifiers: NCT01358513, NCT02132026, NCT00338676, NCT00647088, NCT01679431. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|