Chromosomal terminal methylation status is associated with gut microbiotic alterations
| Autor: | Takahiko Horiuchi, Naoki Makino, Toyoki Maeda |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Aging Somatic cell Clinical Biochemistry Population Biology Gut flora Chromosomes Andrology 03 medical and health sciences 0302 clinical medicine Escherichia coli Humans Intestinal Mucosa education Molecular Biology Telomere Shortening Feces Aged Demethylation education.field_of_study Bacteria Cell Biology General Medicine Methylation DNA Methylation Middle Aged Telomere Inflammatory Bowel Diseases Subtelomere biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology 030220 oncology & carcinogenesis Regression Analysis Female |
| Zdroj: | Molecular and Cellular Biochemistry. 476:157-163 |
| ISSN: | 1573-4919 0300-8177 |
| Popis: | We explored the association of fecal bacterial species and somatic telomere changes in patients with chronic disease. The results showed that the length of the combined range of telomere and the methylated subtelomere was correlated with the increase of bacteria species and the numerical superiority of certain strains in feces, the increase of streptococci in men and women, and the increase of E. coli specifically in women. These results suggest that the aging status reflected by telomere length and/or demethylation of neighboring regions correlate with intestinal conditions which influences the proportion of the intestinal microbial population. Shortened telomere length and subtelomeric demethylation status are thought to represent the degree of aging and the accelerating stage of aging velocity, respectively. Hence, the observed biased microbial status is considered to be associated with advanced stage or acceleration phase of biological aging. |
| Databáze: | OpenAIRE |
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