Recent Progress in Therapeutic Treatments and Screening Strategies for the Prevention and Treatment of HPV-Associated Head and Neck Cancer
| Autor: | Penelope J. Duerksen-Hughes, Maria Filippova, Sonia N. Whang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
medicine.medical_specialty HR HPV lcsh:QR1-502 Review head and neck squamous cell carcinoma HNSCC lcsh:Microbiology Unmet needs Papillomavirus Vaccines Virology Internal medicine Humans Medicine Human papillomavirus Head and neck Early Detection of Cancer Squamous Cell Carcinoma of Head and Neck business.industry target therapy OPSCC Papillomavirus Infections Head and neck tumors Head and neck cancer virus diseases medicine.disease Head and neck squamous-cell carcinoma female genital diseases and pregnancy complications high risk HPV stomatognathic diseases HPV-related oropharyngeal squamous cell carcinoma Infectious Diseases Head and Neck Neoplasms Cohort Carcinoma Squamous Cell cancer treatments business |
| Zdroj: | Viruses, Vol 7, Iss 9, Pp 5040-5065 (2015) Viruses |
| ISSN: | 1999-4915 |
| Popis: | The rise in human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) has elicited significant interest in the role of high-risk HPV in tumorigenesis. Because patients with HPV-positive HNSCC have better prognoses than do their HPV-negative counterparts, current therapeutic strategies for HPV⁺ HNSCC are increasingly considered to be overly aggressive, highlighting a need for customized treatment guidelines for this cohort. Additional issues include the unmet need for a reliable screening strategy for HNSCC, as well as the ongoing assessment of the efficacy of prophylactic vaccines for the prevention of HPV infections in the head and neck regions. This review also outlines a number of emerging prospects for therapeutic vaccines, as well as for targeted, molecular-based therapies for HPV-associated head and neck cancers. Overall, the future for developing novel and effective therapeutic agents for HPV-associated head and neck tumors is promising; continued progress is critical in order to meet the challenges posed by the growing epidemic. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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