Multiple metal exposure and platelet counts during pregnancy: A repeated measure study
| Autor: | Jiaqiang Liao, Yuanyuan Li, Wei Xia, Xiaojie Sun, Aifen Zhou, Bin Lu, Chuansha Wu, Hongxiu Liu, Shuangshuang Bao, Shunqing Xu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
China
medicine.medical_specialty Gestational thrombocytopenia 010504 meteorology & atmospheric sciences Urinary system Urine 010501 environmental sciences 01 natural sciences Gastroenterology Pregnancy Internal medicine medicine Humans Prospective Studies Prospective cohort study lcsh:Environmental sciences 0105 earth and related environmental sciences General Environmental Science lcsh:GE1-350 Platelet Count business.industry Repeated measures design Odds ratio medicine.disease Cross-Sectional Studies Maternal Exposure Metals Gestation Female business |
| Zdroj: | Environment International, Vol 136, Iss, Pp-(2020) |
| ISSN: | 0160-4120 |
| Popis: | Background: Evidence from animal and in vitro studies suggest that some metals interfere with normal platelet counts (PLT). However, limited human studies have investigated the association of metals and PLT, a marker of hematologic and hemostatic, particularly in susceptible populations such as pregnant women. Objectives: Our purpose was to investigate the associations of repeated measures of 13 urinary metals with PLT during pregnancy. Methods: The present study involved 3911 pregnant women participating in a prospective cohort study in Wuhan, China, from 2013 to 2016. We measured 13 metals in urine and PLT in blood samples collected in the first, second, and third trimester (median = 13, 24, and 35 weeks of gestation, respectively). Mixed linear models and general linear models were applied to analyze the associations between multiple metals and PLT during pregnancy. The odds ratio (OR) for gestational thrombocytopenia was examined using generalized estimating equations. Results: After adjusting for other metals and covariates, the repeated measure analyses showed that decreased levels of PLT were associated with a 10-fold increase in urinary concentration of cadmium (Cd) [percent difference (%Δ) = −5.02, 95%CI = −9.53, −0.29], manganese (Mn) [percent difference (%Δ) = −4.63, 95%CI = −7.50, −1.67], and arsenic (As) [percent difference (%Δ) = −4.56, 95%CI = −8.11, −0.86]. Cross-sectional analyses by trimesters revealed that Cd was inversely associated with PLT through the three trimesters. In addition, Cd was associated with an increased OR of 1.80 (95%CI: 1.26, 2.56), 1.65 (95%CI: 1.05, 2.59), 1.54 (95%CI: 1.02, 2.33) for gestational thrombocytopenia in the first, second, and third trimester, respectively. Conclusions: Our study suggested an association of Cd, Mn, and As with decreased PLT during pregnancy. Particularly, Cd may increase the risk of gestational thrombocytopenia. Keywords: Multiple metals, Platelet counts, Gestational thrombocytopenia, Pregnancy |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect