Effects of rimonabant on the development of single dose-induced behavioral sensitization to ethanol, morphine and cocaine in mice
| Autor: | Alexandre J. Oliveira-Lima, R. Wuo-Silva, Renan Santos, Roberto Frussa-Filho, Beatriz M. Longo, André L. Takatsu-Coleman, Camilla L. Patti, Eduardo A.V. Marinho, Thais S. Yokoyama, A.W. Hollais, M.A. Baldaia, Laís F. Berro |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Narcotics Cannabinoid receptor Substance-Related Disorders media_common.quotation_subject medicine.medical_treatment Behavioral sensitization Pharmacology Anxiety Motor Activity Mice Rimonabant Cocaine Dopamine Uptake Inhibitors Piperidines Receptor Cannabinoid CB1 Animals Outbred Strains Medicine Animals Cannabinoid Receptor Antagonists Biological Psychiatry media_common Dose-Response Relationship Drug Ethanol Morphine business.industry Depression Addiction Central Nervous System Depressants Endocannabinoid system Anxiogenic Pyrazoles Cannabinoid business Behavioural despair test medicine.drug Akathisia Drug-Induced |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 58 |
| ISSN: | 1878-4216 |
| Popis: | Rationale The endocannabinoid system has been implicated in the neurobiological mechanism underlying drug addiction, especially the primary rewarding dopamine-dependent processes. Therefore, endocannabinoid receptor antagonists, such as the CB1 cannabinoid antagonist rimonabant, have been proposed as candidates for preventive addiction therapies. Objectives Investigate the possible involvement of CB1 receptors in the development of behavioral sensitization to ethanol, morphine and cocaine in mice. Methods We compared the effects of different doses of rimonabant (0.3, 1, 3 and 10 mg/kg) on spontaneous locomotor activity in the open-field, hyperlocomotion induced by acute administration of ethanol (1.8 g/kg), morphine (20 mg/kg) or cocaine (10 mg/kg) and on subsequent drug-induced locomotor sensitization using a two-injection protocol in mice. We also investigated a possible depressive-like effect of an acute rimonabant challenge at the highest dose and its potential anxiogenic property. Results At the highest dose, rimonabant abolished ethanol- and cocaine-induced hyperlocomotion and behavioral sensitization without modifying spontaneous and central locomotor activity or inducing depressive-like behavior on the forced swim test in mice. The other doses of rimonabant also selectively blocked acute ethanol-induced central hyperlocomotion. Although rimonabant at 0.3 and 1 mg/kg potentiated the central hyperlocomotion induced by acute morphine injection, it was effective in attenuating morphine-induced behavioral sensitization at all doses. Conclusions Because the neural basis of behavioral sensitization has been proposed to correspond to some components of addiction, our findings indicate that the endocannabinoid system might be involved in ethanol, cocaine and morphine abuse. |
| Databáze: | OpenAIRE |
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