Design, Synthesis, and Herbicidal Activity Evaluation of Novel Aryl-Naphthyl Methanone Derivatives
| Autor: | Peng Wang, Jing-Xin Kang, Shuang Gao, Ying Fu, Kui Wang, Fei Ye, Li-Xia Zhao |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
synthesis
design 02 engineering and technology Alkylation 010402 general chemistry 01 natural sciences Acylation lcsh:Chemistry chemistry.chemical_compound Dioxygenase Bioassay herbicidal activity Original Research biology Aryl Active site General Chemistry 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences Chemistry aryl-naphthyl methanone Design synthesis chemistry lcsh:QD1-999 biology.protein 4-hydroxyphenylpyruvate dioxygenase 0210 nano-technology 4-Hydroxyphenylpyruvate dioxygenase |
| Zdroj: | Frontiers in Chemistry, Vol 7 (2019) Frontiers in Chemistry |
| ISSN: | 2296-2646 |
| Popis: | 4-Hydroxyphenylpyruvate dioxygenase (HPPD) is one of the most vital targets for herbicides discovery. In search for HPPD inhibitors with novel scaffolds, a series of aryl-naphthyl methanone derivatives have been designed and synthesized through alkylation and Friedel-Crafts acylation reactions. The bioassay indicated some of these compounds displayed preferable herbicidal activity at the rate of 0.75 mmol/m2 by post-emergence application, in which compound 3h displayed the best herbicidal activity. The molecular docking showed that compound 3h could bind well to the active site of the AtHPPD. This study shows that aryl-naphthyl methanone derivatives could be a potential lead structure for further development of novel herbicides. |
| Databáze: | OpenAIRE |
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