Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg‐like metabolism?

Autor: Carmen Buchrieser, Pedro Escoll
Přispěvatelé: Biologie des Bactéries intracellulaires - Biology of Intracellular Bacteria, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), The Institut Pasteur, the French Region Ile de France (DIM Malinf), the grant no. ANR-10-LABX-62-IBEID and the Fondation pour la Recherche Médicale (FRM), grant No. DEQ20120323697., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Lipopolysaccharides
MESH: T-Lymphocytes/metabolism
Cellular differentiation
T-Lymphocytes
Interleukin-1beta
Mitochondrion
Biochemistry
MESH: Mitochondria/microbiology
Oxidative Phosphorylation
0302 clinical medicine
Glycolysis
MESH: Animals
MESH: Mitochondria/metabolism
MESH: Glycolysis/genetics
MESH: Macrophages/immunology
MESH: Oxidative Phosphorylation/drug effects
Cell Differentiation
MESH: Macrophages/microbiology
MESH: Macrophages/drug effects
MESH: Bacteria/pathogenicity
Cellular Reprogramming
Warburg effect
OXPHOS
3. Good health
Cell biology
Mitochondria
030220 oncology & carcinogenesis
MESH: Bacteria/growth & development
Host-Pathogen Interactions
MESH: Interleukin-1beta/biosynthesis
musculoskeletal diseases
MESH: Cell Differentiation
MESH: Interleukin-1beta/immunology
MESH: Lipopolysaccharides/pharmacology
MESH: T-Lymphocytes/drug effects
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
03 medical and health sciences
Immune system
MESH: Cellular Reprogramming/drug effects
MESH: Cell Proliferation
MESH: T-Lymphocytes/immunology
Animals
Humans
MESH: Macrophages/metabolism
Molecular Biology
Cell Proliferation
MESH: Humans
Bacteria
Cell growth
Intracellular parasite
Macrophages
MESH: Host-Pathogen Interactions
Cell Biology
030104 developmental biology
MESH: Mitochondria/drug effects
MESH: T-Lymphocytes/microbiology
Cancer cell
Warburg-like metabolism
MESH: Mitochondria/immunology
Bacterial infection
Zdroj: FEBS Journal
FEBS Journal, 2018, 285 (12), pp.2146-2160. ⟨10.1111/febs.14446⟩
FEBS Journal, Wiley, 2018, 285 (12), pp.2146-2160. ⟨10.1111/febs.14446⟩
ISSN: 1742-464X
1742-4658
DOI: 10.1111/febs.14446⟩
Popis: This article also appears in: State-of-the-Art Reviews; International audience; The finding that the Warburg effect observed in proliferating cancer cells is also observed during immune responses renewed the interest in the study of metabolic reprogramming of immune cells, a field of investigation called immunometabolism. However, the specific mechanisms and processes underlying metabolic changes of host cells upon bacterial infection remain poorly understood. Several recent reports have reported that mammalian cells infected with intracellular bacteria have an altered metabolism that resembles the Warburg effect seen in cancer cells. In this Review, we will summarize current knowledge on metabolic reprogramming and discuss putative causes underlying the preferential remodelling of host cells to Warburg-like metabolic programs during infection by intracellular bacteria.
Databáze: OpenAIRE
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