| Autor: |
Ayoub, Amssayef, Bouchra, Azzaoui, Ismail, Bouadid, Mohamed, Eddouks |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Cardiovascular & Hematological Disorders-Drug Targets. 21:225-234 |
| ISSN: |
1871-529X |
| DOI: |
10.2174/1871529x21666211214161639 |
| Popis: |
Aims: This work assessed the antihyperglycemic effect of Euphorbia guyoniana. Background: Euphorbia guyoniana (Boss. and Reut.) is widely used in traditional medicine. Objective: This study was designed to confirm this traditional use by assessing its antihyperglycemic capacity in vivo. Methods: The effect of the aqueous extract of Euphorbia guyoniana (Boss. and Reut.) (60 mg/kg) on glycemia in both normal and diabetic rats was evaluated. The glycogen content in the liver and skeletal muscles (extensor digitorum longus and soleus) was measured. Furthermore, liver histopathological analysis was performed. Results: The findings showed that Euphorbia guyoniana (Boss. and Reut.) exhibited a significant decrease in glycaemia in diabetic rats (from 20±2 mmol/l to 5.5 mmol/l after 6 hours of oral administration; p Conclusion: The current study evidenced that Euphorbia guyoniana (Boss. and Reut.) has a beneficial effect on improving hyperglycemia and glycogen depletion in the diabetic state. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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