Constructing an Axonal‐Specific Myelin Developmental Graph and its Application to Childhood Absence Epilepsy
| Autor: | Albert P. Aldenkamp, Mariette H. J. A. Debeij-van Hall, Jacobus F.A. Jansen, Gerhard S. Drenthen, R. Jeroen Vermeulen, Walter H. Backes, Sylvia Klinkenberg, Eric L. A. Fonseca Wald |
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| Přispěvatelé: | Beeldvorming, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Klinische Neurowetenschappen, MUMC+: MA Niet Med Staf Neurologie (9), MUMC+: DA BV Klinisch Fysicus (9), MUMC+: MA Med Staf Spec Neurologie (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty myelin‐water LANGUAGE tractography RADIAL DIFFUSIVITY Lateralization of brain function 030218 nuclear medicine & medical imaging White matter diffusion MRI 03 medical and health sciences Myelin Young Adult 0302 clinical medicine Childhood absence epilepsy AGE RATIO Maturation medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies BRAIN Child Myelin Sheath Original Research business.industry Healthy subjects medicine.disease White Matter Axons medicine.anatomical_structure Cross-Sectional Studies Diffusion Magnetic Resonance Imaging Epilepsy Absence In utero Clinical Investigative Study Female Neurology (clinical) business WHITE-MATTER 030217 neurology & neurosurgery Tractography Diffusion MRI myelin-water |
| Zdroj: | Journal of Neuroimaging Journal of Neuroimaging, 30(3), 308-314. Wiley |
| ISSN: | 1552-6569 1051-2284 |
| Popis: | BACKGROUND AND PURPOSE: The process of myelination starts in utero around 20 weeks of gestation and continues through adulthood. We first set out to characterize the maturation of the tract-specific myelin content in healthy subjects from childhood (7-12 years) into adulthood (18-32 years). Second, we apply the resulting development graph to children with childhood absence epilepsy (CAE), a pediatric epilepsy that was previously characterized by changes in myelin content.METHODS: In a prospective cross-sectional study, 15 healthy children (7-12 years), 14 healthy adult participants (18-32 years) and 17 children with a clinical diagnosis of CAE (6-12 years) were included. For each participant, diffusion weighted images were acquired to reconstruct bundles of white matter tracts and multi-echo multi-slice GRASE images were acquired for myelin-water estimation. Subsequently, a tract-specific myelin development graph was constructed using the percentual difference in myelin-water content from childhood (12 year) to adulthood (25 year).RESULTS: The graph revealed myelination patterns, where tracts in the central regions myelinate prior to peripheral tracts and intra-hemispheric tracts as well as tracts in the left hemisphere myelinate prior to inter-hemispheric tracts and tracts in the right hemisphere, respectively. No significant differences were found in myelin-water content between children with CAE and healthy children for neither the early developing tracts, nor the tracts that develop in a later stage. However, the difference between the myelin-water of late and early developing tracts is significantly smaller in the children with CAE.CONCLUSION: These results indicate that CAE is associated with widespread neurodevelopmental myelin differences. |
| Databáze: | OpenAIRE |
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