Simple additive manufacturing of an osteoconductive ceramic using suspension melt extrusion
| Autor: | Søren Wiatr Borg, Martin Bonde Jensen, Martin A.B. Hedegaard, Nicholas Ditzel, Casper Slots, Torben Thygesen, Ole Albrektsen, Morten Østergaard Andersen, Moustapha Kassem |
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| Rok vydání: | 2016 |
| Předmět: |
Calcium Phosphates
Ceramics Materials science Bone Regeneration Compressive Strength 0206 medical engineering Sintering 02 engineering and technology Bone and Bones chemistry.chemical_compound General Materials Science Ceramic Composite material General Dentistry Carbonization Mesenchymal Stem Cells 021001 nanoscience & nanotechnology Phosphate Microstructure 020601 biomedical engineering Dental Porcelain Compressive strength chemistry Mechanics of Materials visual_art visual_art.visual_art_medium Alkaline phosphatase Implant 0210 nano-technology |
| Zdroj: | Slots, C, Bonde Jensen, M, Ditzel, N, Hedegaard, M A B, Borg, S W, Albrektsen, O, Thygesen, T, Kassem, M & Andersen, M Ø 2017, ' Simple additive manufacturing of an osteoconductive ceramic using suspension melt extrusion ', Dental Materials, vol. 33, no. 2, pp. 198–208 . https://doi.org/10.1016/j.dental.2016.11.012 |
| ISSN: | 1879-0097 |
| DOI: | 10.1016/j.dental.2016.11.012 |
| Popis: | OBJECTIVE: Craniofacial bone trauma is a leading reason for surgery at most hospitals. Large pieces of destroyed or resected bone are often replaced with non-resorbable and stock implants, and these are associated with a variety of problems. This paper explores the use of a novel fatty acid/calcium phosphate suspension melt for simple additive manufacturing of ceramic tricalcium phosphate implants.METHODS: A wide variety of non-aqueous liquids were tested to determine the formulation of a storable 3D printable tricalcium phosphate suspension ink, and only fatty acid-based inks were found to work. A heated stearic acid-tricalcium phosphate suspension melt was then 3D printed, carbonized and sintered, yielding implants with controllable macroporosities. Their microstructure, compressive strength and chemical purity were analyzed with electron microscopy, mechanical testing and Raman spectroscopy, respectively. Mesenchymal stem cell culture was used to assess their osteoconductivity as defined by collagen deposition, alkaline phosphatase secretion and de-novo mineralization.RESULTS: After a rapid sintering process, the implants retained their pre-sintering shape with open pores. They possessed clinically relevant mechanical strength and were chemically pure. They supported adhesion of mesenchymal stem cells, and these were able to deposit collagen onto the implants, secrete alkaline phosphatase and further mineralize the ceramic.SIGNIFICANCE: The tricalcium phosphate/fatty acid ink described here and its 3D printing may be sufficiently simple and effective to enable rapid, on-demand and in-hospital fabrication of individualized ceramic implants that allow clinicians to use them for treatment of bone trauma. |
| Databáze: | OpenAIRE |
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