Leptin and the post-operative inflammatory response. More insights into the correlation with the clinical course and glucocorticoid administration
| Autor: | I. Novikov, S. Ehrlich, Dalit Modan-Moses, D. Lotan, G. Paret, O. Dagan, C. Pariente, Hannah Kanety |
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| Rok vydání: | 2010 |
| Předmět: |
Heart Defects
Congenital Leptin Male medicine.medical_specialty Adolescent Heart disease Endocrinology Diabetes and Metabolism Hemodynamics Methylprednisolone law.invention Postoperative Complications Endocrinology law Internal medicine Cardiopulmonary bypass Humans Medicine Postoperative Period Child Glucocorticoids Inflammation Cardiopulmonary Bypass business.industry Infant Newborn Clinical course Infant Prognosis medicine.disease Systemic Inflammatory Response Syndrome Cardiac surgery Child Preschool Female business hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | Journal of Endocrinological Investigation. 33:701-706 |
| ISSN: | 1720-8386 0391-4097 |
| DOI: | 10.1007/bf03346673 |
| Popis: | Background: Cardiac surgery involving cardiopulmonary bypass (CPB) causes a systemic inflammatory process which can lead to multiple organ failure and postoperative morbidity. Recent animal and human studies suggested a possible involvement of leptin in the systemic inflammatory response. Aim: To characterize the response of leptin to open heart surgery (OHS) and the relationship between the time course of leptin levels and the post-operative clinical course, and to examine the effect of exogenous glucocorticoids. Patients and methods: Forty-seven pediatric patients, undergoing OHS for congenital heart disease were studied. Thirty-four patients (Group 1) received methylprednisolone during CPB while 13 (group 2) did not. Serial blood samples were collected perioperatively and up to 24 h after surgery, and assayed for leptin and cortisol. Results: All patients’ leptin levels decreased significantly during CPB (to 44–48% of baseline, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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