Targeting immunometabolism of neoplasms by interleukins: A promising immunotherapeutic strategy for cancer treatment
| Autor: | Nathan T. Givens, Qian Bai, Yujiang Fang, Hongyun Zhao, Mark R. Wakefield, Conner M. Willson, Pooja Parikh, Ziwen Zhu, Damien B. Beck |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_treatment Biology Metastasis 03 medical and health sciences 0302 clinical medicine Immune system Cancer immunotherapy Stroma Neoplasms Tumor Microenvironment medicine Animals Humans Tumor microenvironment Interleukins Cell Differentiation Immunotherapy medicine.disease Extracellular Matrix 030104 developmental biology Cytokine Oncology Tumor progression 030220 oncology & carcinogenesis Cancer research Energy Metabolism Metabolic Networks and Pathways |
| Zdroj: | Cancer Letters. 518:94-101 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2021.06.013 |
| Popis: | In recent years, tumor metabolism has become a prevalent research topic for scientists and pharmaceutical companies. As research in the field has progressed, the metabolism-based therapy of tumors has ushered in new opportunities. Most tumors emerge and evolve under selective pressure from their microenvironment, which promotes the diversification of both neoplastic and non-neoplastic compartments of the tumor microenvironment (TME), and finally reaches a certain degree of intratumoral heterogeneity. As a result of the tumor intratumoral heterogeneity, tumor cells often possess a complex energy metabolism phenotype. During tumor progression, the metabolism for both tumor parenchyma and stroma is reprogrammed. The tumor stroma mainly consists of the extracellular matrix, fibroblasts, and immune cells. Interestingly, tumor-infiltrating immune cells utilize different metabolites based on their subtype and function, and these immunometabolic pathways can be modified in the TME. In particular, interleukins play a vital role in the activation and differentiation of immune cells and have exhibited multiple effects on tumor cell neoplasia, invasion, and metastasis. In this review, we summarize the common mechanisms of interleukins affecting the tumor and tumor-infiltrating immune cells metabolically and discuss how these mechanisms may lead to novel therapeutic opportunities. This review might contribute to the novel development of cancer immunotherapy. |
| Databáze: | OpenAIRE |
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