Inhibition of tumor growth in mice treated with synthetic muramyl dipeptide
| Autor: | Vakhrusheva Te, Osipov Jg, Jezek J, Bubeník J, Gruntenko Yv, Zolotareva Ag, Vladimir G. Budker, Hofmann J, Zaoral M |
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| Rok vydání: | 1984 |
| Předmět: |
Male
Cancer Research Schedule Ratón Fibrosarcoma Immunology Mice Inbred Strains Pharmacology Drug Administration Schedule chemistry.chemical_compound Mice Liver Neoplasms Experimental parasitic diseases Immunology and Allergy Medicine Animals Tumor growth Neoplasm Metastasis Dipeptide Dose-Response Relationship Drug business.industry body regions Oncology chemistry Liposomes Immunotherapy business Acetylmuramyl-Alanyl-Isoglutamine Muramyl dipeptide |
| Zdroj: | Cancer immunology, immunotherapy : CII. 18(2) |
| ISSN: | 0340-7004 |
| Popis: | Treatment with synthetic MDP inhibited growth of transplantable, chemically induced tumors in syngeneic mice. The tumor-inhibitory effect was dependent on the schedule of MDP administration. Growth of SC transplants of a nonmetastasizing, MC-induced fibrosarcoma, MC11, was inhibited by local treatment with 200 micrograms and 1,000 micrograms MDP given SC 5-7 weeks before challenge. Treatment with lower (10 micrograms and 100 micrograms) doses of MDP and shorter (1-4 weeks) time intervals was not effective. Single doses of MDP (10-1,000 micrograms) 1-3 weeks after challenge had no effect. Growth of IV-inoculated, metastasizing AAT-induced hepatoma A was inhibited by IV injections of 20 micrograms MDP given 1 and 2 days prior to the challenge. Significant increases in the survival of hepatoma-bearing mice were observed only after injections of MDP incorporated in multilamellar liposomes. |
| Databáze: | OpenAIRE |
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