Carbon dioxide and bicarbonate accumulation in caiman erythrocytes during diving
| Autor: | Naim M. Bautista, Christian Damsgaard, Angela Fago, Tobias Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
CROCODYLUS-POROSUS
0106 biological sciences Blood gases Physiology 030310 physiology Bicarbonate Reptile Aquatic Science 010603 evolutionary biology 01 natural sciences Excretion OXYGEN-BINDING 03 medical and health sciences chemistry.chemical_compound Haemoglobin-bicarbonate binding In vivo CROCODILE Molecular Biology Deoxygenation Ecology Evolution Behavior and Systematics 0303 health sciences pH Functional implication Blood-oxygen affinity TRANSPORT ALLOSTERIC REGULATION chemistry Insect Science ALLIGATOR BLOOD Carbon dioxide Biophysics Animal Science and Zoology human activities |
| Zdroj: | Bautista, N M, Damsgaard, C, Fago, A & Wang, T 2021, ' Carbon dioxide and bicarbonate accumulation in caiman erythrocytes during diving ', Journal of Experimental Biology, vol. 224, no. 9, 242435 . https://doi.org/10.1242/jeb.242435 |
| ISSN: | 1477-9145 |
| DOI: | 10.1242/jeb.242435 |
| Popis: | The ability of crocodilian haemoglobins to bind HCO3– has been appreciated for more than half a century, but the functional implication of this exceptional mechanism has not previously been assessed in vivo. Therefore, the goal of the present study was to address the hypothesis that CO2 primarily binds to haemoglobin, rather than being accumulated in plasma as in other vertebrates, during diving in caimans. Here, we demonstrate that CO2 primarily accumulates within the erythrocyte during diving and that most of the accumulated CO2 is bound to haemoglobin. Furthermore, we show that this HCO3– binding is tightly associated with the progressive blood deoxygenation during diving; therefore, crocodilians differ from the classic vertebrate pattern, where HCO3– accumulates in the plasma upon excretion from the erythrocytes by the Cl–/HCO3– exchanger. |
| Databáze: | OpenAIRE |
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