Imaging Findings in Acute Invasive Pulmonary Aspergillosis: Clinical Significance of the Halo Sign
| Autor: | John E. Bennett, Thomas F. Patterson, Olivier Lortholary, Ben E. De Pauw, Patricia Ribaud, David W. Denning, Reginald Greene, Peter F. Troke, Paul Stark, John R. Wingard, Robert H. Rubin, Christine M. Durand, Haran T. Schlamm, J. W. Oestmann, Raoul Herbrecht |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Microbiology (medical) Thorax medicine.medical_specialty Antifungal Agents Adolescent Aspergillosis law.invention Immunocompromised Host Predictive Value of Tests Interventional oncology [UMCN 1.5] law Medical imaging Humans Medicine Clinical significance Child Lung Halo sign Aged Retrospective Studies Lung Diseases Fungal business.industry Middle Aged medicine.disease Survival Analysis Infectious Diseases Predictive value of tests Female Radiology Halo medicine.symptom Tomography X-Ray Computed business Ground glass |
| Zdroj: | Clinical Infectious Diseases, 44, 373-9 Clinical Infectious Diseases, 44, 3, pp. 373-9 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/509917 |
| Popis: | Item does not contain fulltext BACKGROUND: Computed tomography (CT) of the chest may be used to identify the halo sign, a macronodule surrounded by a perimeter of ground-glass opacity, which is an early sign of invasive pulmonary aspergillosis (IPA). This study analyzed chest CT findings at presentation from a large series of patients with IPA, to assess the prevalence of these imaging findings and to evaluate the clinical utility of the halo sign for early identification of this potentially life-threatening infection. METHODS: Baseline chest CT imaging findings from 235 patients with IPA who participated in a previously published study were systematically analyzed. To evaluate the clinical utility of the halo sign for the early identification and treatment of IPA, we compared response to treatment and survival after 12 weeks of treatment in 143 patients who presented with a halo sign and in 79 patients with other imaging findings. RESULTS: At presentation, most patients (94%) had > or =1 macronodules, and many (61%) also had halo signs. Other imaging findings at presentation, including consolidations (30%), infarct-shaped nodules (27%), cavitary lesions (20%), and air-crescent signs (10%), were less common. Patients presenting with a halo sign had significantly better responses to treatment (52% vs. 29%; P |
| Databáze: | OpenAIRE |
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