SIMULTANEOUS OCCURRENCE OF ADVANCED NEUROBLASTOMA AND ACUTE MYELOID LEUKEMIA
| Autor: | Maria Tereza Assis de Almeida, Telma M. Santos-Machado, Paulo T. Maluf, Vicente Odone-Filho, Maria Claudia Nogueira Zerbini, Lillian M. Cristofani, Paula Maria Azevedo |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Oncology medicine.medical_specialty Pathology Neutropenia Cyclophosphamide Leukemia Myelomonocytic Acute Immunophenotyping Neuroblastoma Fatal Outcome Bone Marrow Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Antineoplastic Agents Alkylating Etoposide Cisplatin business.industry Myeloid leukemia Neoplasms Second Primary Hematology medicine.disease Immunohistochemistry Leukemia Child Preschool Pediatrics Perinatology and Child Health Acute myelomonocytic leukemia business medicine.drug |
| Zdroj: | Pediatric Hematology and Oncology. 18:129-135 |
| ISSN: | 1521-0669 0888-0018 |
| DOI: | 10.1080/088800101300002964 |
| Popis: | The authors report the case of a 4-year-old boy with a diagnosis of stage IV neuroblastoma (NB), who had been treated with 6 cycles of cyclophosphamide, doxorubicin, cisplatin, and etoposide for 12 months. The patient reached partial remission and presented a diagnosis of acute myelomonocytic leukemia (M4 AML), confirmed by immunophenotyping. After 2 months of therapy for leukemia, the child died with both malignancies in activity. A necropsy histologically confirmed the simultaneity of the two diseases. The authors review the possibilities of this association. The review leads to the conclusion that AML can occur as a secondary malignancy after the onset of the neuroblastoma, or be suggested by a misdiagnosis. The simultaneous occurrence of both as described here is not, however, found in the literature, to the best of the authors' knowledge. |
| Databáze: | OpenAIRE |
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